前列腺癌发病机制中雄激素和雄激素受体信号的作用

The effect of androgens and androgen receptor signaling on prostate tumorigenesis

雄激素和雄激素受体(AR)信号在前列腺发育和腺体内环境的稳定中是必要的。AR信号几乎驱动着所有前列腺癌细胞的生长。为了驱动前列腺癌生长,在前列腺癌细胞中的AR信号功能得到完好的保留,所以,在转移性前列腺癌中的雄激素和AR信号作用得到了良好地证明。虽然雄激素和AR信号密切参与着正常前列腺的发育和晚期前列腺癌的转移,但是否雄激素和AR信号也参与了前列腺癌的发生和增殖的早期阶段,这一过程依然不明确。本文综述了前列腺组织中雄激素和AR信号的作用,以及前列腺癌从发生到转移至去势抵抗的知识,并阐述了雄激素和AR在前列腺癌启动的早期阶段中的潜在作用。

Androgen and androgen receptor （ AR） signaling is necessary in the development of prostate and the stability of gland internal environment .AR signaling drives almost all the growth of prostate cancer cells .In order to drive the growth of prostate canc-er, prostate cancer cells ’ s AR signals function kept well , we can get good proof about androgen and AR signals in metastatic pros-tate cancer.Although the androgen and AR signals is closely involved in the development of normal development of prostate and ad -vanced prostate cancer metastasis , whether it is also related to the occurrence of prostate cancer or proliferation of prostate cancer in the early stages of the process is still unknown .This review summarizes the role of androgen and and AR signaling in the prostate tis-sue , and the knowledge of prostate cancer from happening to transferring and castration resistance , as well as the potential role of an-drogen and AR signaling in the early stages of prostate cancer .