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线粒体与胰岛素抵抗和糖尿病关系的研究进展

The research progress of the mitochondria's relationship with insulin resistance and diabetes
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摘要 2型糖尿病以胰岛素抵抗为病理基础。虽然膳食、生活方式等环境因素仍被认为是糖尿病的发病中的重要决定因素,但是糖尿病具有明显的家族遗传学基础,而线粒体基因组某些位点的点突变、缺失突变和重复突变均被证明与糖尿病发生密切相关。 Type 2 diabetes is on the pathological basis of insulin resistance .Environmental factors such as diet , lifestyle, though, is still considered an important determinant of the onset of diabetes .However, diabetes have obvious family genetic basis , and some loci point mutation , deletion and repeat mutations of mitochondrial genome are proved to be closely associated with diabetes .
作者 隋小芳 王凤玲 李雪杰 索树珍 杨泽
机构地区 佳木斯大学附属第一医院老年病科 佳木斯大学临床医学院 卫生部北京医院卫生部老年医学研究所
出处 《中国老年保健医学》 2015年第1期16-18,共3页 Chinese Journal of Geriatric Care
基金 黑龙江省教育厅科学技术研究项目(12541828) 国家自然科学基金(81061120527 81370445 81472408) 卫生部公益性研究基金(201302008) 国家科技部十二五支撑计划(2012BAI10B01)
关键词 胰岛素抵抗 糖尿病 线粒体 基因 insulin resistance diabetes mellitus mitochondria gene
分类号 R587.1 [医药卫生—内分泌]
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  • 1Andrews, R.M., Kubacka, I., Chinnery, EE, Lightowlers, R.N., Turnbull, D.M., Howell, N., 1999. Reanalysis and revision of the Cam- bridge reference sequence for human mitochondrial DNA. Nat. Genet. 23, 147.
  • 2Chinnery, EE, Thorburn, D.R., Samuels, D.C., White, S.L., Dahl, H.H.M., Turnbull, D.M., Lightowlers, R.N., Howell, N., 2000. The inheritance of mitochondrial DNA heteroplasmy: random drift, selection or both? Trends Genet. 16, 500-505.
  • 3Cock, EJ., Fields, C.J., Goto, N., Heuer, M.L., Rice, EM., 2010. The Sanger FASTQ file format for sequences with quality scores, and the Solexa/ Illumina FASTQ variants. Nucleic Acids Res. 38, 1767-1771.
  • 4Cree, L.M., Samuels, D.C., Lopes, S., Rajasimha, H.K., Wonnapinij, E, Mann, J.R., Dahl, H.H.M., Chinnery, EE, 2008. A reduction of mito- chondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes. Nat. Genet. 40, 249-254.
  • 5Curwen, G.B., Cadwell, K.K., Winther, J.E, Tawn, E.J., Rees, G.S., Olsen, J.H., Rechnitzer, C., Schroeder, H., Guldberg, E, Cordell, H.J., Boice Jr., J.D., 2010. The heritability of G2 chromosomal radiosensitivity and its association with cancer in Danish cancer survivors and their offspring. Int. J. Radiat. Biol. 86, 986--995.
  • 6Curwen, G.B., Winther, J.E, Tawn, E.J., Smart, V., Whitehouse, C.A., Rees, G.S., Olsen, J.H., Guldberg, E, Rechnitzer, C., Schroder, H., Bryant, EE., Sheng, X., Lee, H.S., Chakraborty, R., Boice, J.D., 2005. G(2) chromosomal radiosensitivity in Danish survivors of childhood and adolescent cancer and their offspring. Br. J. Cancer 93, 1038-1045.
  • 7Danecek, E, Auton, A., Abecasis, G., Albers, C.A., Banks, E., DePristo, M.A., Handsaker, R.E., Lunter, G., Marth, G.T., Sherry, S.T., McVean, G., Durbin, R., 2011. The variant call format and VCFtools. Bioinformatics 27, 2156-2158.
  • 8Durbin, R.M., Altshuler, D.L., Abecasis, G.R., Bentley, D.R., Chakravarti, A. Clark, A.G., Collins, F.S., De La Vega, EM., Donnelly, P., Egholm, M. Flicek, P., Gabriel, S.B., Gibbs, R.A., Knoppers, B.M., Lander, E.S. Lehrach, H., Mardis, E.R., McVean, G.A., Nickerson, D., Peltonen, L. Schafer, A.J., Sherry, S.T., Wang, J., Wilson, R.K., Gibbs, R.A., Deiros, D. Metzker, M., Muzny, D., Reid, J., Wheeler, D., Wang, J., Li, J.X., Jian, M. Li, G., Li, R.Q., Liang, I-I.Q., Tian, G., Wang, B., Wang, J., Wang, W. Yang, H.M., Zhang, X.Q., Zheng, H.S., Lander, E.S., Altshuler, D.L. Ambrogio, L., Bloom, T., Cibulskis, K., Fennell, T.J., Gabriel, S.B. Jaffe, D.B., Shefler, E., Sougnez, C.L., Bentley, D.R., Gormley, N. Humphray, S., Kingsbury, Z., Koko-Gonzales, P., Stone, J. McKernan, K.J., Costa, G.L., Ichikawa, J.K., Lee, C.C., Sudbrak, R.Lehrach, H., Borodina, T.A., Dahl, A., Davydov, A.N., Marquardt, E, Mertes, E, Nietfeld, W., Rosenstiel, E, Schreiber, S., Soldatov, A.V., Timmermann, B., Tolzmann, M., Egholm, M., Affourtit, J., Ashworth, D., Attiya, S., Bachorski, M., Buglione, E., Burke, A., Caprio, A., Celone, C., Clark, S., Conners, D., Desany, B., Gu, L., Guccione, L., Kao, K., Kebbel, A., Knowlton, J., Labrecque, M., McDade, L., Mealmaker, C., Minderman, M., Nawrocki, A., Niazi, E, Pareja, K., Ramenani, R., Riches, D., Song, W., Turcotte, C., Wang, S., Mardis, E.R., Dooling, D., Fulton, L., Fulton, R., Weinstock, G., Durbin, R.M., Burton, J., Carter, D.M., Chnrcher, C., Coffey, A., Cox, A., Palotie, A., Quail, M., Skelly, T., Stalker, J., Swerdlow, H.E, Turner, D., De Witte, A., Giles, S., Gibbs, R.A., Wheeler, D., Bainbridge, M., Challis, D., Sabo, A., Yu, F., Yu, J., Wang, J., Fang, X.D., Guo, X.S., Li, R.Q., Li, Y.R., Luo, R.B., Tai, S., Wu, H.L., Zheng, H.C., Zheng, X.L., Zhou, Y., Yang, H.M., Marth, G.T., Garrison, E.E, Huang, W., Indap, A., Kural, D., Lee, W.E, Leong, W.E, Huang, W.C., Indap, A., Kurai, D., Lee, W.E, Leong, W.E, Quinlan, A.R., Stewart, C., Stromberg, M.P., Ward, A.N., Wu, J.T., Lee, C., Mills, R.E., Shi, X.H., Daly, M.J., DePristo, M.A., Altshuler, D.L., Ball, A.D., Banks, E., Bloom, T., Browning, B.L., Cibulskis, K., Fennell, T.J., Garimella, K.V., Grossman, S.R., Handsaker, R.E., Hanna, M., Hartl, C., Jaffe, D.B., Kemytsky, A.M., Korn, J.M., Li, H., Maguire, J.R., McCarroll, S.A., McKenna, A., Nemesh, J.C., Philippakis, A.A., Poplin, R.E., Price, A., Rivas, M.A., Sabeti, EC., Schaffner, S.E, Sheller, E., Shlyakhter, I.A., Cooper, D.N., Ball, E.V., Mort, M., Phillips, A.D., Stenson, ED., Sebat, J., Makarov, V., Ye, K., Yoon, S.C., Bustamante, C.D., Clark, A.G., Boyko, A., Degenhardt, l., Gravel, S., Gutenkunst, R.N., Kaganovich, M., Keinan, A., Lacroute, P., Ma, X., Reynolds, A., Clarke, L., Flicek, P., Cunningham, F., Herrero, J., Keenen, S., Kulesha, E., Leinonen, R., McLaren, W., Radhakrishnan, R., Smith, R.E., Zalunin, V., Zheng-Bradley, X.Q., Korbel, J.O., Stutz, A.M., Humphray, S., Bauer, M., Cheetham, R.K., Cox, T., Eberle, M., James, T., Kahn, S., Murray, L., Ye, K., De La Vega, F.M., Fu, Y.T., Hyland, EC.L., Manning, J.M., McLaughlin, S.F., Peckham, H.E., Sakarya, O., Sun, Y.A., Tsung, E.E, Batzer, M.A., Konkel, M.K., Walker, J.A., Sudbrak, R., Albrecht, M.W., Amstislavskiy, V.S., Herwig, R., Parkhomchuk, D.V., Sherry, S.T., Agarwala, R., Khouri, H., Morgulis, A.O., Paschall, J.E., Phan, L.D., Rotmistrovsky, K.E., Sanders, R.D., Shumway, M.E, Xiao, C.L., McVean, G.A., Auton, A., Iqbal, Z., Lunter, G., Marchini, J.L. Moutsianas, L., Myers, S., Tumian, A., Desany, B., Knight, J., Winer, R., Craig, D.W., Beckstrom-Sternberg, S.M., Christoforides, A., Kurdoglu, A.A., Pearson, J., Sinari, S.A., Tembe, W.D., Haussler, D., Hinrichs, A.S., Katzman, S.J., Kern, A., Kuhn, R.M., Przeworski, M. Hemandez, R.D., Howie, B., Kelley, J.L., Melton, S.C., Abecasis, G.R. Li, Y., Anderson, P., Blackwell, T., Chert, W., Cookson, W.O., Ding, J. Kang, H.M., Lathrop, M., Liang, L.M., Moffatt, M.E, Scheet, P. Sidore, C., Snyder, M., Zhan, X.W., Zollner, S., Awadalla, P., Casals, F. Idaghdour, Y., Keebler, J., Stone, E.A., Zilversmit, M., Jorde, L., Xing, J.C., Eichler, E.E., Aksay, G., Alkan, C., Hajirasouliha, I. Hormozdiari, E, Kidd, J.M., Sahinalp, S.C., Sudmant, P.H., Mardis, E.R. Chen, K., Chinwalla, A., Ding, L., Koboldt, D.C., McLellan, M.D. Dooling, D., Weinstock, G., Wallis, J.W., Wendl, M.C., Zhang, Q.Y. Durbin, R.M., Albers, C.A., Ayub, Q., Balasubramaniam, S., Barrett, J.C. Carter, D.M., Chen, .A., Conrad, D.E, Danecek, P., Dermitzakis, E.T. Hu, M., Huang, N., Hurles, M.E., Jin, H.J., Jostins, L., Keane, T.M. Keane, T.M., Le, S.Q., Lindsay, S., Long, Q.A., MacArthur, D.G. Montgomery, S.B., Parts, L., Stalker, J., Tyler-Smith, C., Walter, K. Zhang, Y.J., Gerstein, M.B., Snyder, M., Abyzov, A., Abyzov, A. Balasubramanian, S., Bjomson, R., Du, J.A., Grubert, F., Habegger, L. Haraksingh, R., Jee, J., Khurana, E., Lam, H.Y.K., Leng, J., Mu, X.J. Urban, A.E., Zhang, Z.D., Li, Y.R., Luo, R.B., Marth, G.T., Garrison, E.P. Kural, D., Quinlan, A.R., Stewart, C., Stromberg, M.P., Ward, A.N. Wu, J.T., Lee, C., Mills, R.E., Shi, X.H., McCarroll, S.A., Banks, E. DePristo, M.A., Handsaker, R.E., Hartl, C., Korn, J.M., Li, H. Nemesh, J.C., Sebat, J., Makarov, V., Ye, K., Yoon, S.C., Degenhardt, J. Kaganovich, M., Clarke, L., Smith, R.E., Zheng-Bradley, X.Q. Korbel, J.O., Humphray, S., Cheetham, R.K., Eberle, M., Kahn, S. Murray, L., Ye, K., De La Vega, F.M., Fu, Y.T., Peckham, H.E., Sun, Y.A. Batzer, M.A., Konkel, M.K., Xiao, C.L., Iqbal, Z., Desany, B.Blackwell, T., Snyder, M., Xing, J.C., Eichler, E.E., Aksay, G., Alkan, C., Hajirasouliha, 1., Hormozdiari, E, Kidd, J.M., Chen, K., Chinwalla, A., Ding, L., McLellan, M.D., Wallis, J.W., Hurles, M.E., Conrad, D.E, Walter, K., Zhang, Y.J., Gerstein, M.B., Snyder, M., Abyzov, A., Du, J.A., Grubert, F., Haraksingh, R., Jee, J., Khurana, E., Lain, H.Y.K., Leng, J., Mu, X.J., Urban, A.E., Zhang, Z.D., Gibbs, R.A., Bainbridge, M., Challis, D., Coafra, C., Dinh, H., Kovar, C., Lee, S., Muzny, D., Nazareth, L., Reid, J., Sabo, A., Yu, EL., Yu, J., Marth, G.T., Garrison, E.P., Indap, A., Leong, W.E, Quinlan, A.R., Stewart, C., Ward, A.N., Wu, J.T., Cibulskis, K., Fennell, TJ., Gabriel, S.B., Garimella, K.V., Hartl, C., Shefler, E., Sougnez, C.L., Wilkinson, J., Clark, A.G., Gravel, S., Grubert, E, Clarke, L., Flicek, P., Smith, R.E., Zheng-Bradley, X.Q., Sherry, S.T., Khouri, H.M., Pascball, LE., Shumway, M.E, Xiao, C.L., McVean, G.A., Katzman, S.J., Abecasis, G.R., Blackwell, T., Mardis, E.R., Dooling, D., Fulton, L., Fulton, R., Koboldt, D.C., Durbin, R.M, Balasubramaniam, S., Coffey, A., Keane, T.M., MacArthur, D.G., Palotie, A., Scott, C., Stalker, J., Tyler- Smith, C., Gerstein, M.B., Balasubramanian, S., Chakravarti, A., Knoppers, B.M., Peltonen, L., Abecasis, G.R., Bustamante, C.D., Gharani, N., Gibbs, R.A., Jorde, L., Kaye, J.S., Kent, A., Li, T., McGuire, A.L., McVean, G.A., Ossorio, P.N., Rotimi, C.N., Su, Y.Y., Toji, L.H., Tyler-Smith, C., Brooks, L.D., Felsenfeld, A.L., McEwen, J.E., Abdallah, A., Christopher, R., Clemm, N.C., Collins, ES., Duncanson, A., Green, E.D., Guyer, M.S., Peterson, J.L., Schafer, A.J., Abecasis, G.R., Altshuler, D.L., Auton, A., Brooks, L.D., Durbin, R.M., Gibbs, R.A., Hurles, M.E., McVean, G.A., Consortium, G.P., 2010. A map of human genome variation from population-scale sequencing. Nature 467, 1061-1073.
  • 9Elson, J.L., Samuels, D.C, Turnbull, D.M., Chinnery, P.E, 2001. Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age. Am. J. Hum. Genet. 68, 802-806.
  • 10Goto, H., Dickins, B., Afgan, E., Paul, r.M., Taylor, J., Makova, KD., Nekrutenko, A, 2011. Dynamics of mitochondrial heteroplasmy in three fam?ilies investigated via a repeatable re-sequencing study. Genome BioI. 12, R59.

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中国老年保健医学
2015年 第1期

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