电针治疗功能性消化不良大鼠海马体NMDA受体的调节机制

Regulating Mechanism of Electro Acupuncture in the Treatment of Functional Dyspepsia Rats Hippocampus NMDA Receptor

目的:探讨电针治疗功能性消化不良大鼠海马体NMDA受体的调节机制。方法:本项目采用电针足三里、中脘穴作为干预因素,以功能性消化不良大鼠为受试对象,运用免疫组化等多种技术手段,从边缘系统-脊髓-胃肠多水平研究电针对功能性消化不良大鼠胃肠吸收、胃肠动力及神经递质的影响,探讨电针功能性消化不良大鼠海马体NMDA受体通路的分子机理。结果:电针对功能性消化不良大鼠胃肠吸收功能、胃肠动力等有明显影响,电针对功能性消化不良大鼠海马体NMDA受体有显著调节作用。结论:电针治疗功能性消化不良,可能是通过海马体的NMDA受体通路对认知情感中枢与神经内分泌系统进行良性平衡调节而实现的。这一作用的完成,可能是通过通过拮抗海马NMDA受体,进而纠正海马的"兴奋-抑制"失衡,重建稳态来实现的。

Objective.. To explore the regulating mechanism of electro acupuncture in the treatment of functional dys- pepsia rats hippocampus NMDA receptor. Methods： The acupuncture treatment of functional dyspepsia rats and inter- vention measures, to investigate the molecular mechanism of dyspepsia rats hippocampus NMDA receptor pathway from limbic system-acupuncture function of spinal cord. Results： Acupuncture has a significant effect on the regulation of functional dyspepsia rats hippocampus NMDA receptor. Conclusion： Acupuncture treatment of functional dyspepsia, and may be regulated by NMDA receptor pathway of the hippocampus were benign balance.