HMGB1基因上SNP rs1412125与心房颤动的相关性

An association analysis on rs1412125 at HMGB1 with atrial fibrillation

目的：探讨中国汉族人群HMGB1基因上rs1412125与心房颤动之间的关联性。方法：收集396例房颤患者（病例组）和726例对照人群（对照组）,采用病例对照关联分析研究方法,检测HMGB1基因上rs1412125与房颤之间的相关性。结果 ：rs1412125等位基因与基因型分布频率在病例组与对照组中的差异均无统计学意义（等位基因关联分析：观察P=1.05×10^-6,矫正P=0.176;基因型关联分析：加性模式矫正P=0.146,显性模式矫正P=0.162,隐性模式矫正P=0.998）。进一步分析显示,rs1412125等位基因C可显著增加男性风湿性心脏病患者发生房颤的风险（矫正P=2.07×10^-4,矫正OR=8.20,95%CI：2.70~25.0）。结论：HMGB1基因上rs1412125与房颤之间不存在独立相关性,但其与性别、风湿性心脏病之间存在交互效应,可显著增加房颤的发病风险。

Objective To investigate the association of rs1412125 at high-mobility group box 1（HMGB1） gene with atrial fibrillation（AF） in Chinese Han population. Methods 396 patients with AF and726 control subjects were recruited to this study. A case-control association analysis was applied to assess the association between rs1412125 in HMGB1 and AF. Results There were no significant differences in rs1412125 and the frequency of genotype distribution between the study group and the control group（allelic association ：object P value was 1.05E-06, adjust P value was 0.176; genotypic association ： additive P value was 0.146,dominant P value was 0.162, and recessive P value was 0.998）. The interactions analysis showed that rs1412125 allele C increased the risk of AF in male subjects with rheumatic heart disease（adjust P value was 2.07E-04,rectify OR = 8.20, and 95%CI： 2.70-25.0）. Conclusions There is no independent genetic association between rs1412125 at HMGB1 and atrial fibrillation. However, the interactions between rs1412125 and both gender and rheumatic heart disease might increase the risk of atrial fibrillation.