四联与三联疗法在胃溃疡合并幽门螺杆菌感染治疗中的应用效果比较

A comparison of application effect between quadruple and triple therapy on gastric ulcer complicated with Helicobacter pylori infection

目的比较胃溃疡合并幽门螺杆菌(Hp)感染治疗中四联与三联疗法的应用效果。方法选取六盘水市人民医院2011—2013年收治的胃溃疡合并Hp感染患者86例,按照治疗方案分为三联组(雷贝拉唑+阿莫西林+克拉霉素)和四联组(雷贝拉唑+阿莫西林+克拉霉素+胶体果胶铋),每组43例。比较两组患者的临床疗效、Hp清除率及不良反应发生率。结果四联组患者总有效率(88.4%)高于三联组(69.8%)(P<0.05)。四联组患者Hp清除率为86.1%(37/43),高于三联组的67.4%(29/43),差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论四联疗法治疗胃溃疡合并Hp感染的效果显著,能有效提高Hp清除率,且具有一定的安全性。

objective To compare the application effect between quadruple and triple therapy in the treatment of gas-tric ulcer complicated with Helicobacter pylori（ Hp） infection. Methods A total of 86 gastric ulcer patients complicated with Hp infection were selected in the People＆#39;s Hospital of Liupanshui from 2011 to 2013,and they were divided into triple therapy group（ rabeprazole＋amoxicillin＋clarithromycin） and quadruple therapy group（ rabeprazole＋amoxicillin＋clarithromycin＋colloidal bismuth pectin）,43 cases in each group. Curative effect,Hp clearance rate and incidence of adverse reactions between the two groups were compared. Results The total effective rate of quadruple therapy group（88. 4%） was higher than that of triplet therapy group（69. 8%）（P〈0. 05）. The HP clearance rate of quadruple therapy group（86. 1%）was higher than that of triple therapy group（67. 4%）（P〈 0. 05）. There was no significant differences of incidence of adverse reactions be-tween the two groups（P 〉0. 05）. Conclusion Quadruple therapy has remarkable effect in the treatment of gastric ulcer com-plicated with Hp infection,can effectively improve the Hp clearance rate and is safe.