乙酰半胱氨酸泡腾片治疗百草枯致急性肺间质损伤的疗效分析

Clinical efficacy of acetylcysteine effervescent tablets in treating paraquat- induced acute lung interstitial injury

目的探讨乙酰半胱氨酸泡腾片(AET)治疗百草枯(PQ)致急性肺间质损伤的疗效。方法选取2012年1月—2013年6月三峡大学仁和医院呼吸内科收治的由其他科室转入的PQ致急性肺间质损伤患者38例,随机分为对照组和治疗组,各19例。两组均给予血液灌流、抗感染及其他对症治疗,治疗组同时加用AET,治疗8周。观察肺纤维化发生率、病死率和肺功能、动脉血气分析指标。结果治疗组肺纤维化发生率和病死率比对照组低(P<0.05);治疗后治疗组肺总量(TLC)、一氧化碳弥散量(DLCO)、氧合指数(Pa O2/Fi O2)比对照组高,肺泡-动脉血氧分压差〔P(A-a)O2〕比对照组低,差异有统计学意义(P<0.05)。结论 AET治疗PQ致急性肺间质损伤的疗效确切。

objective To investigate the clinical efficacy of acetylcysteine effervescent tablets in treating paraquat—induced acute lung interstitial injury. Methods A total of 38 paraquat—induced acute lung interstitial injury patients were se-lected in Renhe Hospital of Three Gorges University from January 2012 to June 2013,they were randomly divided into control group and treatment group,19 cases in each group. Patients of two groups were treated with hemoperfusion,anti—inflammatory, and other symptomatic treatment,acetylcysteine effervescent tablets were added in treatment group for 8 weeks,the incidence of pulmonary fibrosis,death rate,pulmonary function and arterial blood gas analysis index were observed during the 8 —weeks treatment. Results Incidence of pulmonary fibrosis and death rate of treatment group were lower than control group（ P 〈0. 05）,the total lung capacity（ TLC）,carbon monoxide diffusion capacity（ DLCO）,oxygenation index（ PaO2/FiO2 ）of treatment group were higher than control group,alveolar—arterial biood oxygen partial pressure difference〔P（ A—a） O2〕was lower than control group after treatment（ P〈0. 05）. Conclusion Clinical efficacy of acetylcysteine effervescent tablets in treating paraquat—induced acute lung interstitial injury is accurate.