摘要
目的观察美沙酮对慢性重度癌痛的止痛效果和不良反应。方法选取2012年8月—2013年12月于福建省肿瘤医院住院的晚期恶性肿瘤引起的初治或经吗啡片治疗后疼痛仍控制不佳的癌性疼痛患者97例,97例重度癌痛患者经即释吗啡片滴定后转换为美沙酮,记录使用剂量、达到稳定剂量时间;于美沙酮治疗前后对患者疼痛情况和生活质量进行评估;观察治疗过程中出现的不良反应,并对症治疗。结果患者达到稳定剂量时间平均为(1.0-3.0)d,观察2周后有86.6%的患者疼痛强度(数字分级法)<4分;生活质量部分项目评分(食欲、疲乏、精神状态、睡眠、家庭理解与配合)治疗前后比较,差异有统计学意义(P<0.05);主要不良反应有:头晕、嗜睡、恶心、呕吐、便秘。结论美沙酮治疗重度癌痛的效果显著、快速、安全,患者生活质量明显改善。
objective To observe the analgesic effect and adverse reaction of methadone in treating severe chronic pain of cancer patients. Methods A total of 97 patients with severe cancer pain were selected in Fujian Provincial Tumor Hos-pital from August 2012 to December 2013,they applied oral morphia titration before methadone. Before and after this treatment, using dosage,observation time,intensity of pain,quality of life and adverse reaction of medicine were recorded. Results The time to achieve dose stabilization was（1. 0 —3. 0）days. 86. 6% of patients pain intensity（ digital classification method）was less than 4 points after 2 weeks. There were statistically significant differences in the items of quality of life（ such as appetite, weariness,vigour,sleep,understanding and support from families） before and after treatment（ P〈0. 05）. The main adverse reactions were dizziness,drowsiness,nausea,vomiting,constipation. Conclusion The analgesic effect of methadone in trea-ting severe chronic pain of cancer patients is fast and effective,with slight adverse reactions,the quaity of life of the patients is improved.
出处
《临床合理用药杂志》
2015年第9期23-25,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
疼痛
美沙酮
生活质量
Pain
Methadone
Quality of life
