摘要
目的探讨左氧氟沙星联合阿莫西林克拉维酸钾治疗耐多药肺结核的临床疗效。方法将212例耐多药肺结核患者随机分为观察组和对照组各106例。所有患者均严格给予抗结核化疗,支持治疗和密切护理,观察组给予左氧氟沙星联合阿莫西林克拉维酸钾治疗,对照组仅给予左氧氟沙星治疗。治疗后观察2组临床疗效、病灶吸收程度、空洞闭合情况。结果观察组总有效率为95.28%高于对照组的83.02%,差异均有统计学意义(P<0.05)。观察组病灶吸收率、空洞闭合率均高于对照组,差异均有统计学意义(P<0.05)。结论左氧氟沙星联合阿莫西林克拉维酸钾治疗耐多药肺结核具有良好的治疗效果,且不增加不良反应事件发生率,值得临床推广应用。
Objective To observe the clinical effect of levofloxacin and amoxicillin and clavulanate potassium in MDR-TB.Methods 212 cases patients with MDR-TB were randomly divided into observation group and control group ,each of 106 cases.Observation group was treated by levofloxacin and amoxicillin and clavulanate potassium .Control group was treated by levofloxacin .After treatment ,compared the clinical effect ,lesion extent of absorption ,cavity closure case of 2 groups .Results The total efficacy of observation group （95.28%）was higher than that of control group （83.02%）,the difference was statisti-cally significant（P〈0.05）.The focus absorption rate and cavity closure rate of observation group was higher than that of con -trol group,the difference was statistically significant （ P〈0.05）.Conclusion Levofloxacin and amoxicillin and clavulanate potassium in MDR-TB has an good effect ,worthy of clinical application .
出处
《临床合理用药杂志》
2015年第10期10-11,共2页
Chinese Journal of Clinical Rational Drug Use
