摘要
目的探讨苯磺酸氨氯地平联合贝那普利对维持性血液透析患者左心室重构的影响。方法收集2012年3月-2014年4月来我院就诊的维持性血液透析患者160例,在常规透析药物治疗的基础上给予苯磺酸氨氯地平联合贝那普利治疗。分别于治疗时和治疗后0.5年检测其血清氨基末端脑钠肽(NT-pro BNP)和超敏C-反应蛋白(hs-CRP)水平,同时采用超声心动图检测判其左室重塑变化。结果治疗后0.5年血清NT-pro BNP和hs-CRP水平均低于治疗时,差异均有统计学意义(P<0.05)。经治疗0.5年后患者LVEDD、LVDS、IVST、LVM和LVMI水平低于治疗时,差异均有统计学意义(P<0.05)。其余指标治疗前后变化较小,差异均无统计学意义(P>0.05)。结论苯磺酸氨氯地平联合贝那普利可改善维持性血液透析患者左心室重构,效果较好,值得临床推广应用。
Objective To observe the clinical effect of amlodipine and benazepril in left ventricular remodeling of pa -tients with maintenance hemodialysis patients .Methods Selected 160 cases patients with left ventricular remodeling of pa-tients with maintenance hemodialysis patients from March 2012 to April 2014.All patients were treated by amlodipine and benazepril .Compare the level of NT-proBNP and hs-CRP before and after treatment .Left ventricular remodeling wasdetected by echocardiography .Results The level of NT-proBNP,hs-CRP,LVEDD,LVDS,IVST,LVM and LVMI after treatment were low-er than that before treatment,the difference was statistically significant（P〈0.05）.Other indicators before and after treatment has no statistically significant（P〉0.05）.Conclusion Amlodipine and benazepril in left ventricular remodeling of patients with maintenance hemodialysis patients has an good effect ,worthy of clinical application .
出处
《临床合理用药杂志》
2015年第10期15-16,共2页
Chinese Journal of Clinical Rational Drug Use
