瑞舒伐他汀与阿托伐他汀治疗高胆固醇血症的临床对比观察

The clinical comparative observation of rosuvastatin and atorvastatin in hypercholesterolemia

目的对比瑞舒伐他汀和阿托伐他汀治疗老年高胆固醇血症患者的临床疗效。方法将76例高脂血症患者随机分为研究组和对照组各38例。对照组予阿托伐他汀,研究组予瑞舒伐他汀。于每晚入睡前服用,分别于受试后的4周和8周随访,抽空腹肘静脉血,测定2组TC、TG、LDL-C、HDL-C。结果治疗前2组TC、TG、HDL-C、LDL-C水平差异无统计学意义(P>0.05)。治疗后第4、8周2组TC、TG、LDL-C水平低于治疗前,HDL-C水平高于治疗前,且研究组优于对照组,差异均有统计学意义(P<0.05)。研究组LDL-C达标率为89.5%高于对照组的76.3%,差异均有统计学意义(P<0.05)。结论瑞舒伐他汀组、阿托伐他汀组均能明显降低TC、TG、LDL-C,升高HDL-C,调脂疗效确切。瑞舒伐他汀的临床疗效优于阿托伐他汀,剂量更小,价格相对低廉,安全性相当,值得临床推广使用。

Objective To compare observe the clinical effect of rosuvastatin and atorvastatin in hypercholesterolemia . Methods 76 cases patients with hyperlipidemia were randomly divided into research group and control group ,each of 38 ca-ses.Control group was treated by atorvastatin .Research group were treated by rosuvastatin .After treated,Compared the level of TC、TG、LDL-C、HDL-C after 4,8 weeks of 2 groups.Results The level of TC、TG、HDL-C and LDL-C before treatment was no statistically significant（P〉0.05）.The level of TC、TG、and LDL-C after treatment of 2 groups were lower than that before treatment,the HDL-C was higher than that before treatment ,the difference was statistically significant （P〈0.05）.The level of TC、TG、HDL-C and LDL-C were better than control group,the difference was statistically significant （P〈0.05）.The compli-ance rate of LDL-C of research group（89.5%）was higher than that of control group （76.3%）,the difference was statistically significant（P〈0.05）.Conclusion The clinical effect of rosuvastatin is better than that of atorvastatin .The dose is small,rel-atively inexpensive ,security ,worthy of clinical application .