期刊文献+

青年难治性部分性癫痫应用左乙拉西坦添加治疗的疗效 被引量:7

Study on Effect of Levetiracetam Therapy on Young Patients With Refractory Partial Epilepsy
下载PDF
导出
摘要 目的针对青年难治性部分性癫痫应用左乙拉西坦添加治疗的疗效进行分析。方法随机选择2013年5月-2014年5月期间,我院收治的青年难治性部分性癫痫患者120例,作为本次研究的对象,将其平均分为对照组和观察组,对照组患者实施吡拉西坦治疗,观察组患者实施左乙拉西坦添加治疗。针对两组患者的临床治疗效果、认知功能进行比较。结果观察组患者的临床治疗有效率为88.33%,对照组患者的临床治疗有效率为60.00%,P〈0.05,具有统计学意义。观察组与对照组患者治疗后的认识能力与治疗前比较,有显著差异,P〈0.05,具有统计学意义。观察组与对照组患者治疗后的认知功能有显著差异,P〈0.05,具有统计学意义。结论在青年难治性部分性癫痫治疗中,左乙拉西坦添加治疗可以提高患者的临床治疗有效率,改善患者的认知功能,有良好的治疗效果。 Objective To analysis the therapy efficacy of levetiracetam on youth refractory partial epilepsy. Methods 120 young patients with refractory partial epilepsy from May 2013 to May 2014 in our hospital were randomly selected into 2 groups, the treatment group with levetiracetam and control group with piracetam. The effect and cognitive function were compared after clinical treatment. Results The therapeutic efficacy in the treatment group was significantly higher than that in the control group(88.33% vs 60.00%(P〈0.05).In comparison to the time before treatment, the cognitive ability of the observation group and control group were significantly improved(P〈0.05),the cognitive function of the observation group and control group were significantly improved(P〈0.05). Conclusion Levetiracetam can improve the clinical treatment efficient of patients with youth refractory partial epilepsy, improve the cognitive ability of patients, have good treatment effect, can be applied in clinical treatment.
作者 柴艳萍
出处 《中国继续医学教育》 2015年第7期234-234,共1页 China Continuing Medical Education
关键词 青年 部分性癫痫 左乙拉西坦添加治疗 Youth Partial epilepsy Levetiracetam therapy
  • 相关文献

参考文献2

二级参考文献20

  • 1吴洵昳,洪震,吴逊,吴立文,赵忠新,王学峰,周东,吕传真.多中心双盲、随机、安慰剂对照评价左乙拉西坦添加治疗难治性部分性癫癎发作的疗效及安全性[J].中华神经科杂志,2007,40(3):149-153. 被引量:44
  • 2周波,周东,田林郁,洪震,肖军.左乙拉西坦添加治疗对部分性癫癎患者认知功能及生活质量的研究[J].中华神经科杂志,2007,40(3):154-156. 被引量:10
  • 3Cereghino JJ, Biton V, Abou - Khalil B, et al. Levetiracetam for partial seizures : results of a double - blind, randomized clinical trial. United States Levetiracetam Study Group. Neu- rology,2000,55 ( 2 ) : 236 - 242.
  • 4Morrell MJ,Leppik I, French J, et al. The KEEPER trial : le- vetiracetam adjunctive treatment of partial - onset seizures in an open - label community - based study. Epilepsy Res, 2003,54(2 -3) :153 - 161.
  • 5Abou - Khalil B, Hemdal P, Privitera MD. An open - label study of levetiracetam at individualised doses between 1000 and 3000 mgday( - 1 ) in adult patients with refractory epi- lepsy. Seizure, 2003,12 ( 3 ) : 141 - 149.
  • 6Beran RG, Berkovic SF, Black AB, et al. Efficacy and safety of levetiracetam 1000 - 3000 mg/day in patients with refrac- tory partial - onset seizures : a multicenter, open - label single - arm study. Epilepsy Res ,2005,63 ( 1 ) : 1 - 9.
  • 7Zona C, Niespodziany I, Marchetti C, et al. Levetiracetam does not modulate neuronal voltage - gated Na + and T - type Ca2 currents. Seizure, 2001,10 (4) : 279 - 286.
  • 8Rigo JM , Hans G, Nguyen L, et al. The anti - epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA - and glycine - gated cur- rents. Br J Pharmacol,2002,136 (5) :659 - 672.
  • 9Growder KM, Gunther JM, Jones TA, et al . Abnormal neuro- transmission in mice lacking synaptic vesicle protein 2A ( SV2A). Proc Natl Acad Sei USA, 1999,96 (26) : 15268 - 15273.
  • 10White JR, Walczak TS, Leppik IE, et al. Discontinuation of levetiracetam because of be havioral side efects : a case - con- trolol study. Neurology, 2003,61 (9) : 1218 - 1221.

共引文献83

同被引文献35

二级引证文献35

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部