地诺前列酮栓用于妊娠足月宫颈不成熟孕妇引产的临床效果观察

Observation of Clinical Effect of Propess on Induced Abortion of Full Term Pregnancy With Immature Cervix

目的探讨地诺前列酮栓(欣普贝生)用于足月宫颈不成熟妊娠引产疗效和安全性。方法分析有引产指征的孕妇120例,随机分为观察组和对照组。观察组给予阴道放置一枚欣普贝生引产,对照组给予静脉滴注小剂量缩宫素引产。结果观察组用药12 h、24 h后宫颈Bishop评分及宫颈成熟有效率和自然分娩率明显高于对照组(P<0.05),且平均临产时间明显短于对照组(P<0.05),而两组产后2h出血量及新生儿Apgar评分无明显差异(P>0.05)。结论欣普贝生可提高足月宫颈不成熟有引产指征的孕妇宫颈评分,获得较高的引产疗效,使引产更安全、方便。

Objective To explore the clinical effect and safety of Propess（dinoprostone suppository） for induced abortion of full term pregnancy with immature cervix. Methods 120 pregnant women with indications of induced abortion were selected into observation group and control group randomly. The observation group was treated with Propess in vagina for induced abortion, the control group was treated with a small dose of intravenous oxytocin for induction of labor. Results The Bishop scores, cervical ripening efficiency and natural birth rate in observation group were significantly higher than control group, and average labor time was significantly shorter than the control group（P〈0.05）, but postpartum blood loss and neonatal Apgar scores in two groups were not significantly different（P〈0.05）. Conclusion Propess can improve maternal cervical scores of full term pregnancy with indications of induced abortion, get a high effect of induction of labor, and make induced abortion safe and convenient.