植物凝集素样氧化型低密度脂蛋白受体-1与动脉粥样硬化

Lectin-like oxidized low-density lipoprotein receptor-1 and atherosclerosis

植物凝集素样氧化型低密度脂蛋白受体-1（lectin-likeoxidizedlow-densitylipoprotein receptor-1, LOX-1）是氧化型低密度脂蛋白（oxidized low-density lipoproteins, oxLDL）的主要受体之一。近年来的研究表明，LOX-1不仅可以结合、中和以及降解oxLDL，还能与一些非氧化脂蛋白和凋亡的血细胞结合，通过激活血小板、诱导炎症反应、促进血管平滑肌细胞增殖和迁移等多种途径参与动脉粥样硬化进程。文章从LOX-1的结构、功能及其与脂质代谢、动脉粥样硬化发病机制间的关系等方面，对相关研究进展进行了综述。

Lectin-likeoxidizedLDLreceptor-1（LOX-1）isoneofthemajorreceptorsoftheoxidized low-density lipoproteins （oxLDL）. Recent research suggests that LOX-1 can not only bind, neutralize and degrade oxLDL, but also bind some non-oxidized lipoproteins and apoptotic blood cel s. LOX-1 is involved in the process of atherosclerosis through a variety of w ays, such as activating platelet, inducing inflammatory reaction, promoting the proliferation and migration of vascular smooth muscle cels. This article reviews the related research progress from the relationship betw een the structure and function of the LOX-1 and its lipid metabolism and the pathogenesis of atherosclerosis.