骨髓间充质干细胞治疗脑梗死的研究进展

Research Progress of Bone Marrow Mesenchymal Stem Cell in the Treatment of Cerebral Infarction

骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)是一类具有多项分化潜能的干细胞,通过诱导BMSCs可分化为各胚层细胞。已有动物实验证明,BMSCs治疗能够促进脑梗死后受损神经组织结构和功能的恢复,其可能的机制有:刺激神经发生和突触的形成,分泌多种神经营养因子和细胞因子,发挥免疫调节作用改变缺血区微环境,促进新生血管的形成等。对BMSCs进行修饰处理后,其治疗脑梗死效果更好,临床试验结果较乐观。

Bone marrow mesenchymal stem cells（BMSCs） is a kind of stem cells that have multiple differentiation potential. Through induced, BMSCs can differentiate into each layer cells. Animal experiments proved that BMSCs treatment can promote the recovery of damaged nerve tissue structure and function, and its possible mechanisms are stimulating neurogenesis and the formation of synapses, secreting various neurotrophic factors and cytokines for nerve protection, through the immune adjustment function to change microenvironment of ischemia area, promoting the formation of new blood vessels. Through the modifi cation of BMSCs for treatment, the effect is better, clinical trials have optimistic results.