甘精胰岛素和预混胰岛素联合降糖药改善老年糖尿病患者血糖指标及生活质量影响探究

Effectiveness of Insulin glargine and premixed insulin combined with hypo-glycemic in improving glycemic levels and life quality of old patients with diatetes

目的探讨老年糖尿病患者采用甘精胰岛素和预混胰岛素治疗的效果。方法选择该院2012年1月—2013年12月患者86例,分为两组,各43例,在所有患者同时口服阿卡波糖的基础上,A组每晚10时注射甘精胰岛素1次,而B组每日早晚餐前分别注射预混胰岛素。观察血糖水平、Hb A1c水平、生活质量改善情况。结果 A组胰岛素用量为(13.6±4.7)U/d,明显少于B组(31.3±6.2)U/d(P<0.05)。A组治疗后空腹血糖、餐后2 h血糖、血糖≥10.0 mmol/L曲线下面积所占百分比、糖化血红蛋白水平均明显低于B组(P<0.05)。A组低血糖发生率(6.98%)明显低于B组(37.21%)(P<0.05)。A组SF-36评分高于B组(P<0.05)。结论甘精胰岛素联合阿卡波糖对治疗老年糖尿病患者低血糖具有显著疗效,能显著改善患者生活质量。

Objective To investigate Effectiveness of Insulin glargine and premixed insulin combined with acarbose in improving glycemic levels and life quality of old patients with diadetes. Methods 86 diadetes patients in our hospital from Jan 2012 to Dec2013 were divided into 2 groups, A group were injected with the glargine hypodermically once at 10 O＇clock every night and B group were injected with the mixed insulin hypodermically before the meal of morning and evening respectively, all patients were given oral acarbose at the same time.The glycemic levels and life quality between the 2 groups were compared. Results the doses of insulin in A group（13.6±4.7U/d）were lower than in B group（31.3±6.2U/d）（P〈0.05）. The FBG, 2h PG, Hb A1 c, AUCPG≥10.0mmol / L% in A group were lower than that in B group（P〈0.05）. Scores of eight dimensions of 36-item short-form health survey（SF-36）in observation group were higher than those in control group（P〈0.05. Conclusion Insulin glargine join to acarbose treating old patients with diabetes have ideal effects in controlling glycemic levels with lower risk of hypoglycemia, and can improve the patients＇ life quality.