SPIO和^(19)F探针在MRI活体示踪免疫细胞中的应用

Application of SPIO and ^(19)F probes in magnetic resonance imaging to track in vivo immune cells

日益成熟的体内成像技术,结合不断完善的细胞疗法,推动了体内免疫细胞示踪研究领域的一场变革。随着SPIO探针和19F探针的不断改进,MRI技术的应用范围得以拓展,如借助成像指导的免疫细胞的输送,免疫细胞回归和移植的可视化,以及对炎症和免疫细胞生理变化的监测等。以MRI技术为基础的细胞示踪技术,已被广泛用于示踪活体免疫细胞的去向或评估免疫细胞的疗效。作者着重对SPIO和19F探针在MRI示踪活体免疫细胞的最新进展做一综述。

The increasing confinement of in vivo imaging technologies,combined with the development of emerging cell therapies,has led a revolution in the field of immune cell tracking in vivo. With the rapid improvement of SPIO-and ^19F-based probes,range of magnetic resonance imaging（MRI） application is broadened. For example,MRI technologies have been introduced to image-guided immune cell delivery,and he visualization of immune cell homing and implantation,inflammation,and cell physiology. MRI-based cell tracking technologies have been widely used to follow the fate of immune cells in vivo,or evaluate the effect of cell therapy in vivo. This review focuses on the application of SPIO and ^19 F probes in magnetic resonance imaging to track in vivo immune cells.