小儿肺咳颗粒对痰热壅肺证急性支气管炎患儿的疗效和安全性

Efficacy and Safety of Xiaoer Feike Particles in Treating Lung Phlegm Heat Syndrome in Children with Acute Bronchitis

目的:观察小儿肺咳颗粒治疗痰热壅肺证儿童急性支气管炎有效性和安全性。方法:本研究以本院就诊的150例急性支气管炎痰热壅肺证儿童为研究对象,采用随机平行对照法随机均分为治疗组和对照组。治疗组采用小儿肺咳颗粒进行治疗;对照组采用小儿宣肺止咳颗粒进行治疗,连续治疗8 d后,观察患儿临床症状、疗效及相关不良反应情况。结果:单项症状体征疗效:治疗组的咳嗽、咯痰、肺部特征、发热及咽痛治疗总有效率均高于对照组(P<0.05);疾病疗效:治疗组总有效率为96.00%;对照组总有效率为84.00%,组间差异有统计学意义(P<0.05);中医证候疗效:治疗组总有效率为96.00%;对照组总有效率为85.33%,组间总有效率差异有统计学意义(P<0.05);两组患儿均未出现严重不良反应,两组用药前后生命体征情况差异均无统计学意义。结论:小儿肺咳颗粒治疗痰热壅肺证儿童急性支气管炎疗效显著,且不良反应较少,安全性较高,值得临床推广使用。

Objective： The aim of this article was to investigate the efficacy and safety of Xiaoer Feike particles in the treatment of lung phlegm heat syndrome in children with acute bronchitis. Method： In this study, 150 cases of lung phlegm heat syndrome in children with acute bronchitis in our hospital were taken as research object, and were randomly divided into two groups with 75 cases in each one. Children in treatment group received the treatment of Xiaoer Feike particles; children in treated group received the treatment of Xiaoer Feike particles. The therapeutic efficacy and side effects were observed in the 8-day continuous course. Result： Curative effect of individual signs and symptoms, including the total effective rate of cough, cough up phlegm, lung characteristics, fever and sore throat treatment in treatment group was higher than that in the control group （ P 〈 0. 05 ） ; as for the disease curative effect, the total effective rate in treatment group was 96.00%, while the total effective rate in control group was 84. 00% , the difference between the two groups was statistically significant （P 〈 0. 05） ; in terms of syndromes curative effect, the total effective rate in treatment group was 96. 00%, while the total effective rate in control group was 85.33% , with significant difference between them （P 〈0. 05） ; children in the both groups had no serious adverse reaction, there were no statistically significant difference between before and after medication situation in the both groups for drug vital signs. Conclusion： Effect of Xiaoer Feike particles in treating lung phlegm heat syndrome in children with acute bronchitis is significant and safe, and it is worth promoting in clinical.