淫羊藿苷元制备方法及药理活性研究进展

Preparation Method and Pharmacological Activity of Anhydroicaritin

鉴于淫羊藿苷元特殊的化学结构、广泛、突出的药理活性、较小的毒副作用等特点,表明淫羊藿苷元具有较高的安全性应用前途。本文通过查阅大量国内外相关参考文献,对近年来发表的淫羊藿苷元的制备方法及其药理活性的研究进行整理和分析,为深入开展淫羊藿苷元新制备方法及新药理活性的研究提供参考信息。通过对所查阅文献的分析和总结发现:淫羊藿苷元在淫羊藿体内含量极低,为淫羊藿苷的降解产物,具有雌激素样作用、调节免疫、促进心肌细胞再生和分化、促骨质保护、壮阳、抗肝损伤及延缓肝纤维化、抗肿瘤等多种药理活性。随着国内外对淫羊藿苷元的新药效的发现,未来淫羊藿苷元的国际市场需求很大。因此高效环保地制备淫羊藿苷元的方法将受到广泛的关注。但还缺少对淫羊藿苷元制备方法及药理活性研究的系统回顾与整理。淫羊藿苷元在很多方面较淫羊藿苷及淫羊藿次苷具有更强的药理活性,作为一种新的、低毒和高效的药物,淫羊藿苷元具有广阔的应用空间。为了指导淫羊藿苷元进一步广泛而深入的研究,作者综述了近年来淫羊藿苷元制备方法及药理活性研究的最新进展,发现寻找高效、适合产业化的制备方法将是以后研究的重点及发展方向。为大量制备淫羊藿苷元及合理开发利用提供充足的文献参考依据。

In view of special chemical structure, wide and prominent pharmacological activity, less toxicity and other characteristics of anhydroicaritin, it has indicated that anhydroicaritin has high security and application prospects. By referring the revent literature of preparation methods and pharmacological activity of anhydroicaritin, this paper will provides information to carry out the new preparation methods and new pharmacological activity of anhydroicaritin. Analyzing and summarizing the revent literature, we found that Epimedium brevicornu, has very low levels of degradation products of anhydroicaritin which is the degradation products of icariin, and anhydroicaritin has the effects of estrogen-like, regulation of immune, inflammatory, promoting myocardial cell regeneration and differentiation, promoting bone protection, promoting nerve cell differentiation, impotence, anti-liver injury and fibrosis delay, anti-abnormal proliferative, anti-tumor and blood sugar lowering, and do not find it has significant side effects. With finding the new efficacy of anhydroiearitin at home and abroad, anhydroicaritin has great demand in the international marketin the future. So efficient and environmentally friendly methods for the preparation of anhydroicaritin attract the widespread attention. But it lacks of systematic review and finishing of preparation method and pharmacological activity of anhydroiearitin. anhydroicaritin has stronger pharmacological activity than the icariin and icariside. As a new, low toxicity and efficient drugs, anhydroicaritin has broad application space to guide further extensive and deep research of anhydroicaritin. The author Summarized the latest development of the preparation methods and pharmacological activity of anhydroicaritin in recent years to provide adequate documentation of reference for preparation and rational exploitationfor of anhydroicaritin.