双藤痹痛凝胶膏成型工艺研究

Study on the Forming Process of Shuangteng Bitong Gel Cream

目的:优选双藤痹痛凝胶膏成型工艺条件。方法:以影响凝胶膏膏体成型工艺的炼和速度、干膏粉用量、炼和时间和干燥时间为因素,以初黏力、剥离强度、综合感观(凝胶膏膏体的均匀性、柔软性、涂展性、膜残留性、对皮肤的追随性)为指标进行加权综合评分,以L9(34)正交表优选成型工艺条件并进行验证试验。结果:凝胶膏膏体成型工艺最优条件为炼和速度500 r/min,干膏粉用量3.0 g,炼和时间15 min,干燥时间3 h。验证试验结果表明,按优选结果所制备的凝胶膏综合评分均值为90.06(RSD=0.98%,n=3)。结论:按最优条件制备的凝胶膏黏贴性能良好,各项指标均符合凝胶膏质量要求。

OBJECTIVE：To optimize the forming process of Shuangteng bitong gel cream. METHODS：With the factors of stirring speed,the dosage of dry extract powder,mixing time and drying time related to the gel cream forming process,the indexes of initial adhesive force,peel strength,comprehensive sensory（homogeneity,softness,spreadability,layer residue and tacking strength on skin）were composed weight composite score. L9（3^4）orthogonal array testing was used to optimize the forming process and verification tests were conducted. RESULTS：The optimal gel cream forming process was as follows as stirring speed of 500r/min,dry extract powder of 3.0 g,mixing time of 15 min and drying time of 3 h. The verification tests showed the average score was 90.06（RSD=0.98%,n=3）of the gel cream prepared by the optimized process. CONCLUSIONS：The gel cream prepared by the optimal process has good viscosity character and indexes are in line with the standards of the gel cream quality.