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SOCS2研究进展 被引量：3

Advances in studies on SOCS2
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摘要 细胞因子信号转导抑制因子2(suppressor of cytokine signaling 2,SOCS2)是SOCS家族中的一员,参与调节包括个体生长、代谢、骨形成、肿瘤发生、机体免疫在内的许多生理和病理过程。本文主要从SOCS2的结构、自身活性的调节、在信号转导中的生物学功能以及临床研究等方面,对近年来发表的SOCS2相关文献做一简要概述。 As a member of the suppressor of cytokine signaling（SOCS）protein family,SOCS2 is a negative regulator of cytokine signal transduction which is involved in a variety of aspects of biological and cellular function including growth,metabolism,bone growth,tumorigenesis and immune function.In this article,we mainly review SOCS2 about its molecular structure,the regulation of its activity,biological function in the cytokine signal transduction and clinical research.
作者 崔安芳 黄延红 张向阳
机构地区 济宁医学院基础学院
出处 《济宁医学院学报》 2015年第1期14-18,共5页 Journal of Jining Medical University
基金 济宁医学院2013年度博士基金项目
关键词 SOCS2 生长激素 JAK/STAT信号通路 SOCS2 Growth hormone JAK/STAT signal pathway
分类号 R34 [医药卫生—基础医学]
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参考文献35

  • 1Uren R T,Turnley A M. Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2(SOCS2) is a new player[J ]. Front Mol Neurosci, 2014,7 - 39.
  • 2Wormald S, Hilton D J. Inhibitors of eytokine signal trans- duction[J]. J Biol Chem,2004,279(2) :821-824.
  • 3Fujimoto M, Naka T. Regulation of cytokine signaling by SOCS family molecules[J]. Trends Immunol, 2003,24 (12) : 659-666.
  • 4Kershaw N J ,Murphy J M,Liau N P,et al. SOCS3 binds spe cifie receptor-JAK complexes to control cytokine signaling by direct kinase inhibition[J]. Nat Struct Mol Biol,2013,20(4) : 469-476.
  • 5Metcalf D,Greenhalgh C J,Viney E,et al. Gigantism in mice lacking suppressor of cytokine signalling-2[J]. Nature, 2000, 405(6790) : 1069-1073.
  • 6Rico-Bautista E, Negrin-Martinez C, Novoa-Mogollon J, et al. Downregulation of the growth hormone-induced Janus kinase 2/signal transducer and activator of transcription 5 signaling pathway requires an intact actin cytoskeleton[J]. Exp Cell Res,2004,294(1) :269-280.
  • 7Shen X, Hong F, Nguyen V A, et al. IL-10 attenuates IFN-al- pha-activated STAT1 in the liver:involvement of SOCS2 and SOCS3[J]. FEBS Lett,2000,480(2-3) :132-136.
  • 8Brender C, Nielsen M, Ropke C, et al. Interferon-alpha in duces transient suppressors of cytokine signalling expression in human T cells [J]. Exp Clin Immunogenet, 2001,18 ( 2 ) : 80-85.
  • 9Hu J, Lou D,Carow B, et al. LPS regulates SOCS2 transcrip tion in a type I interferon dependent autocrine-paraerine loop [J]. PLoS One,2012,7(1) :e30166.
  • 10Vesterlund M,Zadjali F, Persson T, et al. The SOCS2 ubiq uitin ligase complex regulates growth hormone receptor levels [J]. PLoS One,2011,6(9) :e25358.

二级参考文献19

  • 1Felson DT. Clinical practice.Osteoarthritis of the knee[J].New England Journal of Medicine,2006,(08):841-848.
  • 2Rico-Bautista E,Flores-Morales A,Fernandez-Perez L. Suppressor of cytokine signaling (SOCS) 2,a protein with multiple functions[J].Cytokine & Growth Factor Reviews,2006,(06):431-439.
  • 3Tollet-Egnell P,Flores-Morales A,Stavreus-Evers A. Growth hormone regulation of SOCS-2,SOCS-3,and CIS messenger ribonucleic acid expression in the rat[J].Endocrinology,1999,(08):3693-3704.doi:10.1210/en.140.8.3693.
  • 4Yasukawa H,Misawa H,Sakamoto H. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop[J].EMBO Journal,1999,(05):1309-1320.
  • 5Yoshimura A,Naka T,Kubo M. SOCS proteins,cytokine signalling and immune regulation[J].Nature Reviews Immunology,2007.454-465.
  • 6Dimitriou ID,Clemenza L,ScoRer AJ. Putting out the fire:coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins[J].Immunological Reviews,2008.265-283.
  • 7Madonna S,Scarponi C,Pallotta S. Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasis[J].Cell Death Dis,2012.e334.
  • 8Minogue AM,Barrett JP,Lynch MA. LPS-induced release of IL-6 from glia modulates production of IL-1 β in a JAK2-dependent manner[J].Journal of Neuroinflammation,2012.126.
  • 9Masood KI,Rottenberg ME,Carow B. SOCS1 gene expression is increased in severe plumonary Tuberculosis[J].Scandinavian Journal of Immunology,2012,(04):398-404.
  • 10da Silva MA,Yamada N,Clarke NM. Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage[J].Journal of Orthopaedic Research,2009,(05):593-601.doi:10.1002/jor.20799.

共引文献5

同被引文献18

引证文献3

二级引证文献1

济宁医学院学报
2015年 第1期

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