摘要
目的：检测慢性萎缩性胃炎和胃腺癌组织中AGR2、P53、GST-π的表达水平,分析其临床意义。方法：对98例慢性萎缩性胃炎、98例胃腺癌和98例正常胃壁组织的病理切片进行HE染色,采用免疫组化法检测病理切片中AGR2、P53、GST-π的表达。结果：AGR2、P53、GST-π在胃腺癌组织中表达量显著高于慢性萎缩性胃炎组织,在慢性萎缩性胃炎组织中的表达量又显著高于正常组织,P〈0.05。AGR2、P53、GST-π在病理分期为Ⅰ-Ⅱ期的胃腺癌患者中表达水平显著低于病理分期为Ⅲ-Ⅳ期者,P〈0.05。结论：AGR2、P53、GST-π的高水平表达与胃癌的发生发展密切相关,综合评估AGR2、P53、GST-π有助于胃癌高危人群早期筛查,以进行预防性的治疗措施。
Objective：To detect the level of the expression of AGR2,P53,GST-πin chronic atrophic gastritis and gastric adenocarcinoma,and analyze its clinical significance.Methods：98cases of chronic atrophic gastritis,98 cases of gastric cancer and 98 cases of normal gastric tissue biopsy were taken for HE staining,and immunohistochemistry method was used to detect the pathological expression of AGR2,P53,GST-π.Results：AGR2,P53,GST-πexpression in gastric adenocarcinoma was significantly higher than that of chronic atrophic gastritis,chronic atrophic gastritis in the expression level was significantly higher than in normal tissue,P〈0.05.The level of expression of AGR2,P53,GST-πin pathologic stageⅠ-Ⅱstage was significantly lower than pathologic stageⅢ -Ⅳ,P〈0.05.Conclusion：The development of high levels of AGR2,P53 and GST-πexpression is closely with gastric cancer.Comprehensive assessment of AGR2,P53,GST-πis contribute to the early screening for the high risk of gastric cancer,and it is good for the preventive treatment.
出处
《医学理论与实践》
2015年第5期566-567,570,共3页
The Journal of Medical Theory and Practice
