外周血淋巴细胞计数对早期宫颈癌手术患者生存状况的预测价值

Predictive value of peripheral blood lymphocyte count for survival status of early cervical cancer patients after surgery

目的:探讨外周血淋巴细胞计数对早期宫颈癌手术患者生存状况的预测价值。方法:对110例早期宫颈癌患者完整的临床病例资料和随访资料进行回顾性分析,所有观察对象均在术前7天和术后的3、7天抽取静脉血做血常规检查。通过单因素log-rank检验和多因素Cox比例风险回归模型方法分析外周血淋巴细胞计数变化对宫颈癌患者生存状况的预测价值。结果:单因素分析结果表明术前低淋巴细胞计数、盆腔淋巴结转移和宫旁浸润与术后无进展生存率有关(P<0.01),多因素分析结果表明术前低淋巴细胞计数和盆腔淋巴结转移是影响宫颈癌患者术后无进展生存率的独立危险因素(P<0.05)。结论:通过计数外周血淋巴细胞,对早期宫颈癌患者术后生存状况有一定的预测意义。

Objective： To explore the predictive value of peripheral blood lymphocyte count for survival status of early cervical cancer patients after surgery. Methods ： The intact clinical data and follow - up data of 110 early cervical cancer patients were analyzed retrospectively, venous blood specimens were obtained for blood routine examination from all the patients at seven days before surgery and three and seven days after surgery. Univariate log - rank test and multivariate Cox proportional hazard model were used to analyze the predictive value of peripheral blood lymphocyte count for survival status of these patients. Results： Univariate analysis showed that preoperative low lymphocyte count, pelvic lymph node metastasis, and parametrial invasion were significantly correlated with postoperative progression -free survival rate （P 〈 0. 01 ） ; multivariate analysis showed that preoperative low lymphocyte count and pelvic lymph node metastasis were inde- pendent risk factors of postoperative progression - free survival rate among early cervical cancer patients （ P 〈 0.05） . Conclusion： Peripheral blood lymphocyte count has a certain predictive value for survival status of early cervical cancer patients after surgery.