骨髓增殖性肿瘤与内皮祖细胞

Myeloproliferative Neoplasms and Endothelial Progenitor Cells——Review

JAK2V617F是骨髓增殖性肿瘤(myeloproliferative neoplasms,MPN)特有的癌基因,与MPN的发病、血管并发症高发生率密切相关。近年研究表明,MPN存在血管内皮损伤,因此内皮细胞及内皮祖细胞(endothelial progenitor cells,EPC)在M PN中的作用逐渐被人们认识,并成为研究热点。本文就EPC JAK2V617F基因突变、外周血中EPC计数在MPN发病及其血管并发症中的作用作一简要综述。

JAK2V617F is a novel oncogene involved in myeloproliferative neoplasms （MPN） and closely related to its vascular complications. Recent researches found the vascular endothelial injury in patients with MPN. It is increasingly being recognized that endothelial cells and endothelial progenitor cells （EPC） play an important role in MPN. Here, the pathogenesis of the EPC JAK2V617F mutation and peripheral blood EPC counts in patients with MPN or with vascular complications are reviewed.