摘要
梅毒治疗后血清学转归包括血清学治愈、血清固定以及血清学失败。血清学治愈是指梅毒患者经推荐方案治疗后，其血清快速血浆反应素环状卡片试验定性转为阴性或定量滴度下降至少4倍或以上。血清固定是指治疗后，患者血清快速血浆反应素环状卡片试验滴度下降到一定水平后，早期梅毒随访6～12个月、晚期梅毒随访12-24个月不再变化或上下波动〈1个滴度的现象。血清学失败是指治疗后梅毒患者血清快速血浆反应素环状卡片试验不降低，出现4倍及以上的上升现象。血清学转归与梅毒临床类型、治疗方案、起始快速血浆反应素环状卡片试验滴度、隐匿性苍白螺旋体感染、是否有人免疫缺陷病毒感染等因素有关。梅毒血清固定患者需要进行非特异性抗体定期检测，必要时给予治疗。血清学失败者，可能是病原体对治疗药物不敏感，应重新治疗。
After treatment for syphilis, serological outcomes include serological cure, serofast state and serological failure. Serological cure means that rapid plasma reagin （RPR） test turns negative or RPR titer decreases by 4 folds or more after recommended anti-syphilitic treatment. Serofast state is defined as that RPR titer drops to a certain level and then remains unchanged or fluctuates by less than 1 fold during 6 - 12 months of follow-up in patients with early syphilis or during 12 - 24 months of follow-up in patients with late syphilis after anti-syphilitic treatment. Serological failure means that RPR titer rises by 4 times or more after anti-syphilitic treatment. Serological outcomes arc related to clinical forms of syphilis, treatment protocols, initial RPR titer, asymptomatic infection with Treponema palladium, human immunodeficiency virus coinfection, etc. Serofast patients with syphilis should undergo periodic detection of nonspecific antibodies and receive treatment when necessary. Serological failure may be attributed to Treponema palladium resistance to given drugs, and retreatment is required for these cases.
出处
《国际皮肤性病学杂志》
2015年第2期133-136,共4页
International Journal of Dermatology and Venereology
基金
广东省科技计划项目（20128031800014）
广州市医药卫生科技项目（20121A031001）
广州市科技计划项目（201300000166）
