人乳头瘤病毒感染与机体固有免疫反应

Human papillomavirus infection and host innate immune responses

人乳头瘤病毒可引起多种疾病，如寻常疣、扁平疣、尖锐湿疣、鲍恩样丘疹病、宫颈癌等。人乳头瘤病毒可以有效地逃逸固有免疫识别，其可能原因包括嗜上皮性、非溶解性复制、高免疫原性的衣壳蛋白在免疫活跃的复层鳞状上皮基底层呈低水平表达等。人乳头瘤病毒的致癌性以及所致疾病的临床高发病率受到人们的广泛关注。机体对抗人乳头瘤病毒的固有免疫已成为研究热点。概述多种皮肤免疫细胞，如角质形成细胞、树突细胞、朗格汉斯细胞、浆细胞样树突细胞、自然杀伤细胞和恒定型自然杀伤T细胞对人乳头瘤病毒固有免疫反应的相关研究。

Human papillomavirus （HPV） can cause a variety of diseases, such as verruca vulgaris, verruca plana, condyloma acuminatum, bowenoid papulosis, cervical cancer, and so on. Moreover, HPV can efficiently escape from the recognization by innate immune system, which may be attributed to epithelial tropism, non-lyric replication, and low expression of capsid protein with high immunogenieity in the basal lamina of immunoactive stratified squamous epithelium. The careinogenieity of HPV and high incidence of HPY-related diseases have received extensive attention. The innate immunity against HPV infection has become a research hotspot. In this review, the authors summarize multiple dermal immune cells involved in the innate immunity against HPV, including keratinocytes, dendritic cells, Langerhans cells, plasmaeytoid dendritic cells, natural killer cells and invariant natural killer T cells.