骨髓间充质干细胞的迁移及其相关力/化学因素调控

Migration and mechanochemical regulation of bone marrow-derived mesenchymal stem cells

骨髓间充质干细胞(mesenchymal stem cells,MSCs)是一类具有自我更新和多向分化潜能的多能干细胞,在损伤组织的修复和再生中起着重要作用。MSCs从骨髓中动员、进入外周血循环向损伤组织位点定向迁移是其行使损伤组织修复功能的关键环节之一。近年来研究证实,多种力学、化学因素在MSCs向损伤组织位点定向迁移过程中起着重要的调节作用。综述MSCs通过外周血循环向损伤组织位点移动过程中相关力学、化学因素对其迁移行为的影响及其可能的分子机理,以期深入认识理化因素及其耦合对MSCs迁移行为的影响特征,为体外调控MSCs的高效迁移从而更好地应用于临床发挥其组织修复功能提供理论指导。

Bone marrow-derived mesenchymal stem cells（ MSCs） are a kind of multi-functional stem cells with self-renewal and multi-lineage differentiation potentials,which play an important role in repair and regeneration of damaged tissues. The MSCs mobilization from bone marrow and migration through peripheral circulation into injured tissues are a key function of MSCs for tissues repairing. It has been proved in resent years＇ studies that various mechanical and chemical factors play a significant part in regulating the directed migration of MSCs to the damaged tissue. In this paper,the effects of mechanical and chemical factors on migration of MSCs through peripheral blood circulation to the damaged tissue are reviewed,and the possibly involved molecule mechanisms are discussed,trying to further understand the mechanochemical coupling in this process,and to provide the theoretical guidance for making mechanochemistry-induced efficient migration of MSCs in tissue repair in clinic.