慢性荨麻疹Phadiatop和Fx5E试验结果及意义

Detection of Phadiatop and Fx5E in chronic urticaria and its significance

目的了解乌鲁木齐地区慢性荨麻疹患者变应原分布情况,为临床治疗和预防提供依据。方法乌鲁木齐地区慢性荨麻疹患者230例,其中年龄≤14岁29例(儿童组),>14岁201例(成人组);采集患者静脉血分离血清后应用固相免疫荧光法进行吸入物变应原Phadiatop试验和食物变应原Fx5E试验。结果本组变应原检测总阳性率为47.39%,sIgE分级≥3级阳性率为26.96%;Phadiatop试验阳性率(41.30%)以及sIgE分级≥3级阳性率(22.61%)高于Fx5E试验阳性率(17.83%)和sIgE分级≥3级阳性率(11.74%),差异均有统计学意义(P<0.05);儿童组Phadiatop、Fx5E试验中sIgE分级≥3级阳性率(24.14%、17.24%)高于成人组(22.39%、10.95%),但差异均无统计学意义(P>0.05)。结论吸入性变应原是乌鲁木齐地区慢性荨麻疹发生的主要因素,儿童患者发病与食物变应原关系密切。

Objective To search for a basis for the therapy and prevention of chronic urticaria by investigating its allergen distribution in Urumqi.Methods A total of 230 patients with chronic urticaria in Urumqi were divided into child group（n=29）aged ≤14years and adult group（n=201）aged 〉14years.The concentrations of serum Phadiatop and Fx5 E were measured by solid-phase immunofluorescence.Results The total positive rate was 47.39%.The positive rate was26.96% among those with sIgE ≥3grade.The positive rates of Phadiatop test（41.30%）and of those with sIgE ≥3grade（22.61%）were higher than those of Fx5Etest（17.83%）and of those with sIgE ≥3grade（11.74%）,showing significant differences（P〈0.05）.The positive rates of sIgE ≥3grade in Phadiatop and Fx5 Etest were higher in child group（24.14%,17.24%）than those in adult group（22.39%,10.95%）,but there were no significant differences（P〉0.05）.ConclusionInhaled allergen is the main factor of chronic urticaria in Urumqi area.The onset of children urticaria is more closely correlated with food allergens.