超体质量及肥胖成人肺通气功能与炎性因子相关性分析

Relationship of pulmonary function with inflammatory mediators in overweight and obese adults

目的探讨超体质量、肥胖成人肺通气功能与炎性因子的相关性。方法 90例成人体检者按体质量指数分为正常组、超体质量组、肥胖组各30例。采用ELISA法检测3组肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、细胞间黏附分子-1(intercellular cell adhesion molecule-1,ICAM-1)水平,并进行肺通气功能检测;分析肺通气功能与TNF-α、IL-6、ICAM-1的相关性。结果肥胖组肺活量(vital capacity,VC)(92.37±6.45)%、用力肺活量(forced vital capacity,FVC)(93.27±7.78)%、第1秒用力呼气容积(forced expiratory volume in one second,FEV1)(89.87±9.43)%、最高呼气流速(peak expiratory flow,PEF)(78.00±11.18)%均较正常组(VC(96.43±5.99)%、FVC(101.4±15.41)%、FEV1(98.90±13.85)%、PEF(87.40±10.98)%)明显降低(P<0.05或P<0.01),超体质量组上述指标(VC(93.07±7.30)%、FVC(96.27±6.91)%、FEV1(95.10±10.77)%、PEF(80.03±21.62)%)与正常组、肥胖组比较差异均无统计学意义(P>0.05);肥胖组中TNF-α((0.82±0.05)μg/L)、IL-6((86.86±3.80)ng/L)较正常组(TNF-α为(0.79±0.05)μg/L、IL-6(84.82±2.86)ng/L)明显增高(P<0.05),超体质量组上述指标(TNF-α(0.80±0.05)μg/L、IL-6(85.22±3.79)ng/L)与正常组、肥胖组比较差异均无统计学意义(P>0.05),各组间ICAM-1水平比较差异无统计学意义(P>0.05);TNF-α与FVC、FEV1呈负相关(r=-0.285,P=0.006;r=-0.269,P=0.010),ICAM-1与VC呈负相关(r=-0.230,P=0.042)。结论肥胖者存在肺功能受损及部分炎症介质改变;炎症介质与肥胖通气功能受损相关。

Objective To investigate the relationship of pulmonary function with inflammatory mediators in overweight and obese adults.Methods According to the body mass index,90 health volunteers were divided into normal weight group,overweight group and obese group,with 30 patients in each group.The serum tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6）and intercellular adhesion molecule-1（ICAM-1）levels were measured by ELISA.Pulmonary function was measured.The correlations of pulmonary function with TNF-α,IL-6and ICAM-1were analyzed.Results Vital capacity（VC）,forced vital capacity（FVC）,forced expiratory volume in one second（FEV1）and peak expiratory flow（PEF）were significantly lower in obese group（（92.37±6.45）%,（93.27±7.78）%,（89.87±9.43）%,（78.00±11.18）%）than those in normal weight group（（96.43±5.99）%,（101.4±15.41）%,（98.90±13.85）%,（87.40±10.98）%）（P〈0.05,P〈0.01）,showing no significant differences in comparison with those in overweight group（（93.07±7.30）%,（96.27±6.91）%,（95.10±10.77）%,（80.03±21.62）%）（P〉0.05）.TNF-αand IL-6 were significantly higher in obese group（（0.82±0.05）μg/L,（86.86±3.80）ng/L）than those in normal weight group（（0.79±0.05）μg/L,（84.82±2.86）ng/L）（P〈0.05）,showing no significant differences in comparison with those in overweight group（（0.80±0.05）μg/L,（85.22±3.79）ng/L）（P〉0.05）.There was no significant difference in ICAM-1level among groups（P〉0.05）.TNF-αwas negatively correlated with FVC and FEV1（r=-0.285,P=0.006;r=-0.269,P=0.010）.ICAM-1was negatively correlated with VC（r=-0.230,P=0.042）.Conclusion Impaired pulmonary function and inflammatory mediator disorders exist in obese adults.Inflammatory mediators are involved in pulmonary function damage.