调节性B细胞在类风湿性关节炎中的研究进展

Advance of regulatory B cells in rheumatoid arthritis

研究发现某些B细胞能够通过产生调节性的细胞因子(如IL-10、TGF-β)或者直接与病原性的T细胞相互作用抑制免疫反应,这类B细胞亚群被定义为regulatory B(Breg)cells。类风湿性关节炎(rheumatoid arthritis,RA)是一种以关节滑膜炎为特征的、伴随骨和软骨结构进行性破坏、最终导致关节破坏和畸形的慢性炎症疾病。已证实Breg在关节炎小鼠模型(collageninduced arthritis,CIA)以及类风湿性关节炎患者中发挥了免疫抑制作用。本文主要总结了近年来国内外有关Breg在RA疾病方面的研究进展,阐述其在RA中可能的作用机制,为RA疾病的预防、治疗提供新思路。

Previous studies show that certain B cells can negatively regulate the immune response by producing regulatory cytokines, such as IL-10 and TGF-β, or directly interacting with pathogenic T cells, which are defined as regulatory B（Breg） cells. Rheumatoid arthritis is a chronic inflammatory disease characterized by inflammation in the synovium as well as the progressive destruction of cartilage and bone structures, which eventually leads to joint destruction and deformity. Immune suppressive functions of Breg have been demonstrated in collagen-induced arthritis（CIA） and RA patients. This review mainly concentrates research advance of Breg in RA disease at home and abroad in recent years and try to illustrate its role in the RA mechanism, in order to provide new opinion on treatment and prevention of disease.