唐山市城镇健康居民体检血清高密度脂蛋白胆固醇水平的分布

The characteristics of serum high-density lipoprotein cholesterol levels in urban population from Tangshan City

目的通过对唐山市城镇居民健康体检人群血清高密度脂蛋白胆固醇（HDL—C）水平分析，了解血清HDL—C在健康体检人群中的分布特点。方法回顾性研究。收集唐山市工人医院自2009年1月至2013年12月间36454名健康体检者临检资料，为尽量保证检测对象的健康程度，剔除了明确患病人群以及肝脏功能受损、血糖异常、肾损伤等其他人群。有效数据共计25197例，其中男性11114例，女性14083例。依据年龄划分为6组，使用匀相法检测血清HDL—C水平。数据采用R3．0．2统计学分析软件进行统计分析。采用Kolmogorov—Smimov进行正态分布检验，再采用kruskal—wallistest及Dunn muhiple comparisontest进行多组问非参数性检验。结果整体人群中血清HDL-C平均数为（1．22±0．31）mmol/L，低于1．30mmol／L的全国平均水平。血清HDL-C水平男女性别差异较大，女性血清HDL-C中位数（1．27mmol／L）水平明显高于男性（1．08mmol／L）（x^2=2606．34，P〈0．01）。男性血清HDL-C水平随年龄增长有增高的趋势，其中位数水平由1．06mmol／L升高至1．11mmol／L，且50岁以上年龄组高于50岁以下各年龄组，差异有统计学意义（x^2=75．19，P〈0．01）。依据2007年中国血脂异常防治指南，健康体检人群中29．69％（7481／25197）的个体低于1．04mmol／L，尤其在男性人群中，其异常检出率高达42．94％（4772／11114）。结论唐山市城镇地区血清HDL-C水平低于全国平均水平，且男性血清HDL—C水平随年龄呈阶梯形升高趋势。

Objective To understand the characteristics of High-density lipoprotein cholesterol （HDL-C） distribution through analyzing serum HDL-C levels in healthy checkup subjects among local urbauese. Methods The checkup results of 36 454 cases were collected from 2009 to 2013 in Tangshan Gongren hospital（male： n = 20 343, female： n = 16 111 ）. The cases with liver injury, abnormal blood glucoses , kidney injury and defined cerebrovascular diseases and metabolic disease were excluded. 25 197 cases were analyzed as normal subjects including 11 114 males and 14 083 females. Kolmogorov-Smimov test, kruskal-wallis test, and Dunn multiple comparison test was performed using Bioconductor software 3.0. 2 for testing normality distribution and comparing the difference of two or multiple groups, respectively. Results were analyzed statistically with R 3.0. 2. Results The results showed that the average level （1. 22± 0. 31 ） mmol/L of HDL-C among the overall population is lower than that of national average level（ 1.30 mmo//L）. The median serum HDL-C level in female is higher than in male （1. 27 and 1.08, X^2 = 2 606. 34, P 〈0. 01 ）. HDL-C levels in male continuously increase from 1.06 mmol/L to 1.11 mmol/L with aging, especially in groups of over 50 years old than in groups of below 50 years old （X2 = 75. 19, P 〈 0. 01 ）. Conclusions Based on 2007 guidance on prevention and treatment by national health bureau, this study showed that there are 29.69% of the apparent healthy subjects, especially about 42. 94% of the male,representing low HDL-C level under the low limit of 1.04 mmol/L. These results showed that serum HDL-C level in Tangshan urbanese is lower than that of national average level, and HDL-C level in male is tended to increase with aging.