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高迁移率族蛋白B1在肠道炎症和肿瘤中的作用 被引量:2

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摘要 高迁移率族蛋白B1(high mobility group box 1protein,HMGB1)由Wang等[1]在1999年发现,在炎症晚期的作用已被大量的研究所证实,HMGB1不仅在脓毒症的致死过程中发挥重要作用,还与风湿性关节炎、失血性休克、慢性肝病、恶性肿瘤、缺血再灌注等发病有关。
出处 《临床消化病杂志》 2015年第1期49-51,共3页 Chinese Journal of Clinical Gastroenterology
基金 国家自然科学基金资助(No:81000159 No:81472311)
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  • 1WANG H,BLOOM O,ZHANG M,et al. HMG-1 as a late mediator of endotoxin lethality in mice[J]. Science, 1999,285: 248- 251.
  • 2YANG H,WANG H,CZURA C J, et al. The cytokine activity of HMGBI[J]. J Leukoc Biol, 2005,78 : 1 - 8.
  • 3HUANG W,TANG Y,LI L. HMGBI,a potent proin flammatory cytokine in sepsis[J]. Cytokine, 2010,51 : 119-126.
  • 4BIANCHI M E, MANFREDI A A. High-mobility group box 1 (HMGB1)protein at the crossroads be tween innate and adaptive immunity[J]. Immunol Rev, 2007,220:35-46.
  • 5THOMAS J. O. HMG1 and 2 :architectural DNA-bind- lag proteins[J]. Biochem Soc Trans, 2001,29 (Pt 4) 395-401.
  • 6STROS M, STOKROVA J, THOMAS J O. DNA looping by the HMG-box domains of HMG1 and modulation of DNA binding by the acidic C-terminal domain [J]. Nucleic Acids Res,1994,22:1044-1051.
  • 7YOUN J H,SHIN J S. Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward seeretion[J]. J Immunol, 2006,177: 7889-7897.
  • 8FU M,WANG C,ZHANG X,et al. Acetylation of nu- clear receptors in cellular growth and apoptosis [J]. Biochem Pharmacol, 2004,68: 1199 - 1208.
  • 9ORLOVA V V,CHOI E Y,XIE C,et al. A novel path- way of HMGBl-mediated inflammatory cell recruit- ment that requires Mac-l-integrin[J]. EMBO J, 2007, 26:1129-1139.
  • 10YANG D, CHEN Q, YANG H, et al. High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin[J]. J Leukoc Biol,2007,81:59-66.

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