期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脓毒症免疫紊乱及免疫调节治疗 被引量：2

Immune dysfunction and immuno - modulatory therapy on sepsis
原文传递
导出
摘要 脓毒症免疫抑制及不良预后关系引起了广泛关注，免疫调节治疗一直是重症医学领域的研究热点之一。多项研究显示提升淋巴细胞功能可改善脓毒症的预后，现将脓毒症免疫紊乱、免疫调节的研究现状进行归纳，探讨免疫调节治疗脓毒症的价值。 The relationship between immuno - suppression and poor prognosis of sepsis causes widely concern. Immuno - modulatory therapy is one of the research hotspots in critical medical care. Some studies have shown that to enhance the function of lymphocyte might improve the prognosis of septic patients. This paper will review the immune dysfunction and explore the value of immuno - modulatory therapy in process of sepsis.
作者 张琪
机构地区 首都儿科研究所附属儿童医院重症医学科
出处 《中华实用儿科临床杂志》 CAS CSCD 北大核心 2015年第6期405-408,共4页 Chinese Journal of Applied Clinical Pediatrics
关键词 脓毒症 免疫紊乱 免疫调节治疗 Sepsis Immune dysfunction Immuno - modulatory therapy
分类号 R459.7 [医药卫生—急诊医学]
  • 相关文献

参考文献32

  • 1Calvano SE, Xiao WZ, Richards DR, et al. A network-based analysis of systemic inflammation in humans] J J. Nature,2005 ,437 (761) : 1032 - 1037.
  • 2Bone RC. Sir Isaac newton,sepsis,SIRS,and CARS[J]. Crit Care Med, 1996,24(7) :1125 -1128.
  • 3MarshallJC. Such stuff as dreams are made on: mediator-directed therapy in sepsis[J]. Nat Rev Drug Discov,2003,2(5) :391-405.
  • 4Opal SM, Laterre PF, Francois B, et al. Effect of eritoran, an antagonist of MD2- TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial[J].JAMA,2013 ,309( 11) : 1154 -1162.
  • 5BoomerJS, To K, Chang KC, et al. Immunosuppression in patients who die of sepsis and multiple organ failure[J].JAMA, 2011 ,306 (23) : 2594 -2605.
  • 6Felmet KA, Hall MW, Clark RS, et al. Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure[J].J Immunol,2005,174(6) :3765 -3772.
  • 7Drewry AM, Samra N, Skrupky LP, et al. Persistent lymphopenia after diagnosis of sepsis predicts mortality[J]. Shock, 2014,42 (5) : 383 - 391.
  • 8Torgersen C ,Moser P , Luckner G, et al. Macroscopic postmortem findings in 235 surgical intensive care patients with sepsis[J]. Anesth Analg, 2009,108(6) :1841 -1847.
  • 9Kollef KE, Schramm GE, Wills AR, et al. Predictors of 30-day mortality and hospital costs in patients with ventilator-associated pneumonia attributed to potentially antibiotic-resistant gram-negative bacteria[J] . Chest ,2008,134 (2) :281 - 287.
  • 10Luyt CE, Combes A, Deback C, et al. Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation[J] . AmJ Respir Crit Care Med ,2007 ,175 (9) :935 - 942.

二级参考文献46

  • 1冯国辉,雷志礼,宇鹏,宁新宇,韦中余,李军,刘多辉,董兰,韩暑君,李会光.乌司他丁对原位肝移植术患者围术期肾功能的影响[J].中华麻醉学杂志,2005,25(11):853-855. 被引量：3
  • 2Toshiyuki Yano.Neuroprotective Effect of Urinary Trypsin Inhibitor against Focal Cerebral Ischemia-Repeffusion Injury in Rats.Anesthesiology,2003,98:465-473.
  • 3Angus DC,Linde-Zwirble WT,Lidicker J,et al.Epidemiology of severe sepsis in the United States:analysis of incidence,outcome and associated costs of care.Crit Care Med,2001,29:1303-1310.
  • 4Bone RC,Balk RA,Cerra FB,et al.Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis:ACCP/SCCM Consensus Conference Committee.Chest,1992,101:1644-1655.
  • 5Marshall JC,Cook DJ,Christou NV,et al.Multiple organ dysfunction score:A reliable descriptor of a complex clinical outcome.Crit Care Med,1995,23:1638-1652.
  • 6Dellinger RP,Carlet JM,Masur H,et al.Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock.Crit Care Med,2004,32:858 -873.
  • 7Cronin L,Cook DJ,Carlet J,et al.Corticosteroid treatment for sepsis:a critical appraisal and meta-analysis of the literature.Crit Care Med,1995,23:1430-1439.
  • 8Natanson C,Esposito C J,Banks SM.The sirens' songs of confirmatory sepsis trials:selection bias and sampling error.Crit Care Med,1998,26:1927-1931.
  • 9Bone RC.Sir Isaac Newton,sepsis,SIRS,and CARS.Crit Care Med,1996,24:1125-1128.
  • 10Richard S Hotchkiss,Irene E Karl.The pathophysiology and Treatment of Sepsis.N Engl J Med,2003,348:138-150.

共引文献98

同被引文献17

引证文献2

二级引证文献26

中华实用儿科临床杂志
2015年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部