早产儿支气管肺发育不良易感基因研究进展

Research progress of post - susceptibility genes with bronchopulmonary dysplasia in premature infants

支气管肺发育不良（bronchopulmonary dysplasia，BPD）是早产儿最常见的严重慢性呼吸道疾病。近年来随着超早产儿成活率提高，BPD发病率明显增加，约10％的机械通气新生儿可发生BPD，对社会和家庭均可造成严重影响。早产儿BPD的病因多种多样，国外近期研究表明，其易感性可能与遗传因素有关，国内初步研究亦提示BPD汉族早产儿可能存在多个易感基因。现将近年来有关早产儿BPD易感基因的研究进展作一综述。

Bronchopulmonary dysplasia （BPD） is one of the most common serious chronic respiratory diseases in premature infants. In recent years, BPD has been significantly increasing with the improved survival rate of extremely preterm babies. About 10% of neonates with mechanical ventilation might suffer from BPD,and this may lead to a great burden and costs to both the family and the society. A variety of risk factors has been proposed to be associated with BPD in preterm infants. However recent abroad researches indicated that genetic factors might predispose to BPD of preterm neonates, and initial results of domestic related researches inferred that several susceptibility genes might contribute to BPD development in Han preterm infants. This review focuses on recent publications related to genetic factors that may potentially contribute to BPD.