摘要
目的:分析帕米膦酸二钠不良反应的发生规律及特点,为合理用药提供参考。方法:检索1995-2014年4月"中国学术期刊全文数据库(CNKI)"、"维普中文科技期刊数据库(VIP)"收载的帕米膦酸二钠不良反应文献进行分析。结果:22例不良反应中,男13例,女9例,年龄50岁以上患者较多(16例,72.8%),用药1周内出现不良反应9例(40.9%),用药1年后出现不良反应7例(31.8%),累及的器官或系统以肌肉骨骼系统损害为主(11例,50.0%)。结论:临床医师、药师应了解帕米膦酸二钠致不良反应的规律和特点,加强用药监测,减少不良反应的发生。
OBJECTIVE To analyze the general patterns and characteristics of adverse drug reactions(ADRs)induced by Pamidronate(APD)and provide references for clinical medication.METHODS ADRs of APD reported from1995 to April2014 retrieved in CNKI and VIP were collected and analyzed statistically.RESULTS Totally 22 cases of ADRs caused by APD were collected,including 13 men and 9 women.Patients over the age of 50 years showed the highest incidence(n=16,72.8%).Nine cases of ADRs caused by APD attacked within 1 week after injection and 7 cases of ADRs 1 year layer.The ADRs were mainly involved in disorders of musculoskeletal system(n=11,50.0%).CONCLUSION Clinicians and pharmacists should be familiar the patterns and characteristics of ADRs induced by APD,and closely monitoring pamidronate administration to reduce relevant ADRs.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2015年第6期528-531,共4页
Chinese Journal of Hospital Pharmacy