摘要
Objective:To determine the optimum treatment for viral myocarditis(VMC).Methods:A total of 126 VMC patients were randomly divided into the control group(42 cases) that was treated with conventional Westem medicine,and the intervention group(84 cases) that was treated with a combination of Chinese medicine(CM)and Western medicine intervention termed optimum proposal of integration of disease and syndrome(OPIDS).Before and after 4 weeks of treatment,the integral of CM syndrome,self-rating depression and anxiety scales(SDS and SAS,respectively),echocardiograms(ECGs),heart rate variability and left ventricular systolic function were observed.Results:Compared with the control group,the intervention group showed significant reductions on the SDS and SAS(P〈0.05);improvement of premature ventricular beats,atrioventricular blocks,ST-segment abnormalities,and significant T wave changes(P〈0.05);greater reductions in standard deviation of NN intervals(SDNN),standard deviation for per 5 min averages NN intervals(SDANN),and root-mean-square of successive difference of NN intervals(rMSSD)(P〈0.05);and increases in cardiac output,stroke volume,and ejection fraction,the last of which was statistically significant(P〈0.05).Overall,the treatment efficacy rate was significantly better(P〈0.05) in the intervention group(75.61%) compared with the control group(69.70%).Conclusion:OPIDS is quite effective in treating VMC and improves symptoms such as anxiety and depression,left ventricular systolic dysfunction,premature ventricular contraction,and cardiac autonomic nervous system dysfunction.[Registration:Chinese clinical trial center(No.ChiCTR-TRC-00000298)]
Objective:To determine the optimum treatment for viral myocarditis(VMC).Methods:A total of 126 VMC patients were randomly divided into the control group(42 cases) that was treated with conventional Westem medicine,and the intervention group(84 cases) that was treated with a combination of Chinese medicine(CM)and Western medicine intervention termed optimum proposal of integration of disease and syndrome(OPIDS).Before and after 4 weeks of treatment,the integral of CM syndrome,self-rating depression and anxiety scales(SDS and SAS,respectively),echocardiograms(ECGs),heart rate variability and left ventricular systolic function were observed.Results:Compared with the control group,the intervention group showed significant reductions on the SDS and SAS(P〈0.05);improvement of premature ventricular beats,atrioventricular blocks,ST-segment abnormalities,and significant T wave changes(P〈0.05);greater reductions in standard deviation of NN intervals(SDNN),standard deviation for per 5 min averages NN intervals(SDANN),and root-mean-square of successive difference of NN intervals(rMSSD)(P〈0.05);and increases in cardiac output,stroke volume,and ejection fraction,the last of which was statistically significant(P〈0.05).Overall,the treatment efficacy rate was significantly better(P〈0.05) in the intervention group(75.61%) compared with the control group(69.70%).Conclusion:OPIDS is quite effective in treating VMC and improves symptoms such as anxiety and depression,left ventricular systolic dysfunction,premature ventricular contraction,and cardiac autonomic nervous system dysfunction.[Registration:Chinese clinical trial center(No.ChiCTR-TRC-00000298)]
基金
Supported by the 11th Five-year Plan National Science and Technology Support Program(No.2007BAI20B073)