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蛋白质量控制研究 被引量：3

Protein Quality Control
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摘要 细胞内蛋白的质量控制包括新翻译蛋白的正确折叠组装以及错误折叠蛋白的降解。生物体内精确的蛋白质量控制机制维持着细胞的正常生理功能,蛋白质量控制异常通常与肿瘤、衰老等多种退行性疾病的发生有关。该文对胞质、内质网以及线粒体内的蛋白质量控制机制进行了综述,旨在为全面了解蛋白质量控制异常相关疾病的发生提供参考。 Protein quality control（PQC） is a surveillance system ensuring the proper folding of newly synthesized protein and degradation of damaged or misfoldered protein. Dysregulation of PQC system has been implicated in cancer, aging and other degenerative diseases. To provide a comprehensive understanding of PQC in human diseases, the role of PQC in cytosol, endoplasmic reticulum and mitochondria are discussed in this review.
作者 石号 孙大燕 李宾 方合志 吕建新
机构地区 温州医科大学检验医学院
出处 《中国细胞生物学学报》 CAS CSCD 2015年第2期241-248,共8页 Chinese Journal of Cell Biology
基金 国家自然科学基金(批准号:81101506)资助的课题~~
关键词 蛋白质量控制 分子伴侣 内质网 线粒体 protein quality control chaperon endoplasmic reticulum mitochondria
分类号 Q51 [生物学—生物化学]
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参考文献55

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同被引文献49

  • 1YUE WenTao1, ZHAO XiaoTing1, ZHANG LiNa1, LIU ZhiDong2, MA Li1, JIA WenYun1, QIAN Zhe1, ZHANG ChunYan1, WANG Yue1, YANG XueHui1 & XU ShaoFa2 1 Department of Cellular Biology, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China,2 Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China.Overexpression of cyclin Y in non-small cell lung cancer is associated with cancer cell proliferation[J].Science China(Life Sciences),2010,53(4):511-516. 被引量：10
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二级引证文献5

中国细胞生物学学报
2015年 第2期

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