自噬与代谢及代谢性疾病

Autophagy, Metabolism and Metabolic Diseases

细胞自噬是真核生物中一种高度保守的代谢过程,可以清除受损的细胞器,降解糖原、脂类、蛋白质等生物大分子物质供细胞重新利用,对维持细胞内代谢平衡有重要意义。自噬障碍常被发现与代谢性疾病相关,如酸性麦芽糖酶缺乏症、肥胖和神经退行性疾病等。该文就近年来关于自噬与代谢及代谢性疾病的研究作一综述。

Autophagy is a highly-conserved metabolic process in eukaryotes. It serves to clear damaged organelles, degrade glycogen, lipids and protein for cellular metabolic reuse, and it plays an important role in the homeostasis of cellular metabolism. Autophagic dysfunctions are often found to be involved in metabolic diseases, such as Pompe disease, obesity and neurodegenerative diseases. Here we reviewed the studies on the relationship about autophagy, metabolism and metabolic diseases in recent years.