细胞自噬调控的分子机制研究进展

Research Progress of the Molecular Mechanism of Autophagy Regulation

细胞自噬是一种进化上保守的分解代谢过程,涉及细胞内长寿命蛋白和受损伤细胞器的降解,其在细胞内稳态、肿瘤、心力衰竭、衰老相关性疾病、神经退行性疾病以及传染病等多种生命进程中发挥着重要作用。泛素样蛋白系统、m TOR信号通路、micro RNA、caspase等均参与了细胞自噬调控过程。该文综述了细胞自噬过程、功能和分子调控机制的研究进展,以期有助于研究细胞自噬机理,为治疗心脏疾病(如动脉粥样硬化)、癌症(如乳腺癌)等提供理论基础。

Autophagy, as an evolutionarily conserved catabolic process, involves in intracellular long-lived protein and damaged organelles catabolism. Autophagy plays an important role in a variety of life processes, such as the cell homeostasis, tumor, heart failure, aging-related diseases, neurodegenerative disease and infectious diseases. Ubiquitin protein system, m TOR signaling pathway, micro RNA and caspase mediate autophagy regulation. Therefore, we summarized the research progress of the autophagy process, function and molecular mechanism in the article to help research autophagy mechanism and provide theoretical basis for treating certain diseases.