Dmrt1与哺乳动物生殖细胞发育

Dmrt1 in Mammalian Germ Cell Development

Dmrt1是Dmrt(doublesex and mab-3 related transcription factor)基因家族成员之一,其在哺乳类、鸟类、爬行类、线虫和果蝇等多种物种中存在,是目前已知的最为保守的一个与性别分化相关的基因。该基因在性别分化期的雄性性腺及雄性成体的精巢中特异性表达,对于雄性性腺的形成和功能维持具有重要作用。该文主要简述Dmrt1在调节哺乳类动物生殖细胞发育、分化方面的研究进展及其存在的问题。

Dmrt1 is a member of the Dmrt（doublesex and mab-3 related transcription factor） family, which exists in mammals, birds, reptiles, nematodes, fruit fl ies and other species. It is known as the most conservative gene that participates in the gender differentiation. It is expressed in the male gonad during gender differentiation as well as in the adult testis specifically, with a significant effect on the formation and function of male gonads. This review mainly focuses on the research and problems which exist in mammalian germ cell development and differentiation regulation by Dmrt1.