功能性消化不良与脑肠肽的研究进展

Functional dyspepsia and brain-gut peptides

功能性消化不良(functional dyspepsia,FD)是临床常见的胃肠道动力疾病和消化内科多发病,FD的发病机制与多种因素有关,但目前尚未阐明其确切的病因及发病机制.FD属于典型的身心疾病,FD与精神心理因素相互作用的发病机制与脑肠轴的调节障碍有关,其主要包括中枢神经系统对异常刺激的处理和脑肠肽(brain-gut peptides,BGP)水平的异常.BGP是脑肠轴靶向作用的分子基础,脑肠轴通过脑肠互动作用调控相关BGP水平的变化,从而影响FD的发病.目前发现与FD相关的BGP有15余种,相关BGP多在下丘脑、延髓、脊髓、胃肠黏膜表达,本文从相关BGP的分泌及作用机制来阐明其水平变化与FD发病的关系.

Functional dyspepsia（FD） is a frequently occurring gastrointestinal disorder, but its etiology and pathogenesis are still unclear because it is associated with multiple factors. As a typically physical and psychological disease, the role of psychological factors in the pathogenesis of FD involves the brain-gut axis, mainly abnormal stimulation processing by the central nervous system and abnormal levels of brain-gut peptides. Brain-gut peptides are the molecular basis of the action of the brain-gut axis, and the brain-gut axis affects the occurrence of FD by regulating the levels of brain-gut peptides. So far, 15 brain-gut peptides associated with FD have been found, which are predominantly expressed in the hypothalamus, medulla oblongata, spinal cord and gastrointestinal mucosa. The aim of this study is to clarify the relationship between brain-gut peptide levels and the occurrence of FD based on brain-gut peptide in terms of their secretion and mechanisms of action.