慢性萎缩性胃炎复发的危险因素

Risk factors for recurrence of chronic atrophic gastritis: A comparative study

目的:探讨各种可能危险因素与慢性萎缩性胃炎(chronic atrophic gastritis,CAG)复发风险的关系,为胃癌癌前病变的个体化预防提供科学依据.方法:CAG病变经中药治疗后胃镜检查痊愈的患者560例,其中再次发病的病例84例作为复发组,在余下的476例未复发的健康患者中用SAS 9.2统计软件生成随机序列号随机抽取84例作为对照组,即未复发组,两组共168例;对两组多种危险因素进行描述性对比分析.结果:与未复发组比较,复发组中的胃溃疡个人史、服用阿司匹林等非甾体药的使用、主食汤泡饭、服用复合维生素(如善存)、每日食用水果差异有统计学意义(P<0.05).结论:胃溃疡个人史、服用阿司匹林等非甾体抗炎药的使用、主食汤泡饭对萎缩性胃炎的复发有一定促进作用,服用复合维生素(如善存)和每日食用水果对萎缩性胃炎的复发有一定抑制作用.

AIM： To investigate the risk factors for recurrence of chronic atrophic gastritis（CAG）. METHODS： Five hundred and sixty patients who underwent previous treatment for CAG were initially enrolled, including 84 recurrent cases and 476 non-recurrent cases. The 84 recurrent cases served as an experimental group, and 84 cases were selected randomly from the 476 non-recurrent cases to comprise a control group. A comparative study was performed between the two groups to identify the risk factors for CAG recurrence. RESULTS： There were significant differences in personal history of gastric ulcer（GU）, usage of nonsteroidal anti-inflammatory drugs（such as aspirin）, mixed meal of rice and soup, daily consumption of fruit, and daily multivitamin tablets between the two groups. CONCLUSION： Personal history of gastric ulcer, usage of non-steroidal drugs（aspirin）, and mixed meal of rice and soup are risk factors for the relapse of CAG; daily consumption of fruit and daily multivitamin tablets are protective factors.