β-连环素和血管内皮生长因子在肝细胞癌中的表达及意义

Significance of expression of β-catenin and VEGF in hepatocellular carcinoma

目的:探讨β-连环素(β-catenin)和血管内皮生长因子(vascular endothelial growth factor,VEGF)在肝细胞癌中的表达以及相关性.方法:应用免疫组织化学方法检测48例肝细胞癌及16例正常肝组织β-catenin及VEGF的表达情况.结果:β-catenin在正常组织呈正常表达,在肝细胞癌中异常表达,VEGF在正常细胞呈阴性,肝细胞癌中高表达(P<0.05);在肝细胞癌组织中,VEGF的高表达和β-catenin异常表达有相关性(P<0.05,r=0.361);β-catenin和VEGF的异常表达与临近组织侵犯、肿瘤直径相关(P<0.05).结论:在肝癌组织中,β-catenin和VEGF的表达有关联性;β-catenin在肝癌组织的表达和VEGF的高表达与肿瘤直径、临近组织侵犯相关.

AIM： To investigate the expression of β-catenin and vascular endothelial growth factor（VEGF） in hepatocellular carcinoma（HCC） and to analyze their significance.METHODS： The expression of β-catenin and VEGF was detected in 48 HCC and adjacent HCC tissues and 16 normal liver tissues by immunohistochemical method. RESULTS： The expression of β-catenin was normal in the 16 cases of normal liver tissues but abnormal in HCC. The expression of VEGF was normal in normal liver tissues but high in HCC tissues（P 〈 0.05）. There was a association between the abnormal expression of β-catenin and the high expression of VEGF in HCC tissues（P 〈 0.05, r = 0.361）. The abnormal expression of β- caten in and VEGF were positively correlated with invasion to adjacent tissues and tumor diameter（P 〈 0.05）.CONCLUSION： The expression of VEGF was associated with expression of β-catenin in HCC, abnormal expression of β-catenin and high expression of VEGF were related to tumor diameter and invasion of adjacent tissues.