74例癫痫孤残儿童药物治疗分析

Analysis of medication treatment on 74 children with epilepsy

目的:通过对74例癫痫孤残儿童抗癫痫药物治疗临床观察分析,积累儿童福利机构孤残儿童抗癫痫治疗经验。方法:以进行抗癫痫药物治疗的74例癫痫孤残儿童为对象,依据2013年7月观察期起始时使用抗癫痫药物种类数量情况进行分组,单药治疗组38例,联合用药组36例,观察各组儿童抗癫痫药物治疗效果,并进行统计分析。结果:经过抗癫痫药物治疗的74例癫痫孤残儿童,总治疗有效率为78.4%,其病情得到明显缓解;单药治疗组疗效有效率84.2%,联合用药组为72.2%,两组患儿疗效存在显著差异(P<0.05)。结论:上海市儿童福利院癫痫孤残儿童需尽早、长期、系统、正规抗癫痫药物治疗,有利于癫痫疾病的控制,提高癫痫孤残儿童的生活质量。

Objective:To accumulate experience in treating abandoned and disabled children with epilepsy in the childrenˊs welfare center, through clinical observation and analysis of 74 cases with epilepsy treated by antiepileptic drugs. Methods:74 cases with epilepsy treated by the antiepileptic drugs were selected and divided into monotherapy group (n=38) and combination group (n=36 ) according to the species and quantity of the used antiepileptic drugs from July 2013 observation period. The treatment effects of the two groups were observed and statistically analyzed. Results:Among the 74 cases, the total effective rate of the treatment was 78. 4%, and the conditions of the disease were significantly alleviated. The effective rates of monotherapy group and combination group were 84. 2% and 72. 2%, respectively, and the difference was significant (P﹤0. 05). Conclusions: It is necessary for the children with epilepsy in Shanghai childrenˊs welfare center to receive the long-term, systematic, and regular antiepileptic drug therapy as soon as possible, which is better to control the seizures for the children with epilepsy and improve their quality of life.