补肾益精丸治疗肾阴虚型男性不育症患者临床研究

Clinical Observation of Bushen Yijing Wan for Treatment of Male Infertility with Syndrome of Kidney Yin Deficiency

目的:观察补肾益精丸治疗肾阴虚型男性不育症患者的临床疗效。方法:收集60例肾阴虚型男性不育症患者,均采用补肾益精丸治疗,3月为1疗程,共治疗2疗程。比较患者治疗前、后临床症状的改善情况,检测精子活动力和精子黏附卵子的能力。结果:本组60例患者,经2疗程的治疗后,20例患者配偶怀孕,受孕率为33.3%。患者五心烦热、盗汗口干、腰膝酸软、舌红少苔、脉细数等症状积分较治疗前降低,差异均有统计学意义(P<0.05)。对其中10例有做完整精子活动力检测及精子-透明质酸结合分析法(HBA)检验的患者资料统计后发现,治疗后a、b、c级精子活动力以及精子黏附卵子能力较治疗前均有明显改善(P<0.05)。结论:补肾益精丸可有效改善肾阴虚型男性不育症患者的临床症状、精子活动力和精子黏附卵子能力,提高患者配偶受孕率。

Objective：To explore the effect of Bushen Yijing Wan for kidney yin deficiency male infertility with abnormal sperm activity and sperm-hyaluronan binding activity. Methods：Sixty cases were enrolled into the study and were treated with Bushen Yijing Wan for 2 courses lasting 6 months. The relief of clinical symptoms was evaluated before and after treatment, and 10 cases with complete data of routine semen detection and sperm-hyaluronan binding assay（HBA） were subject to statistical analysis. Results：After treatment,the spouses of 20 cases from the 60 cases were pregnant,and the pregnant rate was 33.3%. The symptom scores of burning sensation of five centres,night sweat and dry mouth,sore-tired waist and knee,red tongue with less fur,thin and rapid pulse were decrease after treatment（P 0.05 compared with before treatment）. For the 10 cases with complete data, sperm activity and sperm-hyaluronan binding ability were improved after treatment（P 0.05 compared with those before treatment）. Conclusion： Bushen Yijing Wan can effectively improve clinical symptoms, sperm activity and sperm-hyaluronan binding ability, and promote spouse pregnant rate.