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GLP-1及其类似物治疗糖尿病的研究进展 被引量：4

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摘要 胰高血糖素样肽-1(GLP-1)是一种肠源性激素,具有促进胰岛素分泌、抑制胰高血糖素释放,改善胰岛β细胞功能,促进胰岛β细胞增殖并抑制其凋亡、延缓胃排空以及保护心血管等重要作用。天然的GLP-1在体内被二肽基肽酶-4(DPP-4)迅速降解,因此很难在临床中直接应用。GLP-1类似物可以抵抗DPP-4的降解,增强与GLP-1受体的结合,有效延长作用时间,具有很好地应用前景。该文就GLP-1及其类似物的作用特点、临床应用、潜在风险和不良反应等最新研究进展作一综述。
作者 盛灵通 孔建龙 秦健 管其君
机构地区 浙江华阳药业有限公司
出处 《糖尿病新世界》 2015年第2期22-23,共2页 Diabetes New World Magazine
关键词 胰高血糖素样肽-1 GLP-1类似物 糖尿病 临床应用
分类号 R587.1 [医药卫生—内分泌]
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参考文献15

  • 1Xu Y, Wang L, He J,et al. Prevalence and control of diabetes in Chi-nese adults[J]. JAMA, 2013,310(9):948-959.
  • 2Hoist J.The physiology of glucagon-like peptide-l[J].Physician Rev, 2007, 87(4):1409.
  • 3Alarcon C,Alcamtara A.Renal catabolism of truncated glucagon-like peptide-1 Ruiz-Grande CI[J]. Horm Metab Res, 1993,25(12):612-616.
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  • 5刘瑞,胡仁明,王庆华.GLP-1类似物：糖尿病预防和治疗的新型药物[J].中国糖尿病杂志,2008,16(8):509-511. 被引量：12
  • 6Holz GG.New insights concerning the Slucose-dependent insulin secret-agogue action of glucagon-like peptide-1 in pancreatic beta-cells[J].Horm Metab Res,2004,36(11-12):787-794.
  • 7Farilla L1,Bulotta A,Hirshberg B.Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets[J].Endocrinology,2003,144(12):5149-5158.E-pub 2003 Aug 28.
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二级参考文献24

  • 1Wang Q,Brubaker PL. Glucagon like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice. Diabetologia, 2002,45 : 1263-1273.
  • 2Baggio LL, Drueker DJ. Therapeutic approaches to preserve islet mass in type 2 diabetes. Annu Rev Med,2006,57:265-281.
  • 3Holz GG. New insights concerning the glucose-dependent insulin secretagogue action of glucagon like peptide-1 in pancreatic beta cells. Horm Metab Res, 2004,36 : 787-794.
  • 4Kang G, Joseph JW, Chepurny OG, et al. Epac-selective cAMP analog 8-pCPT-2'-O Me-cAMP as a stimulus for Ca^2+ induced Ca^2+ release and exocytosis in pancreatic beta cells. J Biol Chem, 2003,278:8279- 8285.
  • 5Wang Q,Li L,Xu E,et al. Glucagon like peptide-1 regulates pro liferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells. Diabetologia, 2004,47 : 478 -487.
  • 6Bouckenooghe T, Vandewalle B, Lukowiak B, et al. Modulation of specific beta cell gene (re)expression during in vitro expansion of human pancreatic islet cells. Cell Transplant, 2003,12 : 799-807.
  • 7Toft-Nielsen MB, Madsbad S, Holst JJ. Continuous subcutaneous infusion of glucagowlike peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients. Diabetes Care, 1999,22: 1137-1143.
  • 8Buteau J,El-Assaad W, Rhodes CJ, et al. Glueagon-like peptide 1 prevents beta cell glueolipotoxieity. Diabetologia, 2004, 47: 806-815.
  • 9Bregenholt S, Moldrup A, Blume N, et al. The long-acting gluca gon like peptide-1 analogue, liraglutide, inhibits beta cell apopto sis in vitro. Biochem Biophys Res Commun, 2005,330 : 577-584.
  • 10Kendall DM,Riddle MC, Rosenstock J, et al. Effects of exenatide (exendin 4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care, 2005,28 : 1083 1091.

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糖尿病新世界
2015年 第2期

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