应用人嗜碱粒细胞脱颗粒试验对肺螨病免疫病理机理的探讨

APPLICATION OF HUMEN BASOPHILES DEGRANULATION TEST (HBDT) TO RESEARCHES OF THE IMMUNOPATHOTOGIC ASPECTS OF PULMONARY ACARIASIS

关于肺螨病的致病机理,迄今为止的研究认为主要与螨类入侵人体呼吸系统并寄生于肺部所引起的机械性损伤,以及螨体的或其代谢或分泌性的抗原刺激宿主机体所产生的过敏反应有关。为了进一步探讨肺螨病的致病机理及摸索免疫诊断的新方法,我们在测定肺螨病患者血清免疫球蛋白的基础上,应用改良方法对37例肺螨病患者进行人嗜碱粒细胞脱颗粒试验,获得了较满意的效果。

The modified method of hurnen basophiles degranulation test(HBDT)has been used for the first time in the study of immunopathological reaction of pulmonary acariasis. In 37 cases the positive rate was 89. 19% which higher obviously than that of the control and the concordance of the results between HBDT and skin test reached 86. 44%. The total IgE average value of the patients' sera was 2953. 8IU/ml which increased obviously compared with that of the control. The results demonstrated that there was allergic antibodies caused by specific antigen on the surface of the patients' basophiles, so we thought that the allergic reaction has important significance in the pathologic mechanisms. The results also indicated that HBDT was a useful method for pulmnary acariasis diagnosis.