丹参多酚酸盐对脑梗塞患者脑血流动力学的影响

Effect of salvianolate on cerebral hemodynamics in patients with cerebral infarction

目的探讨丹参多酚酸盐对脑梗塞患者脑血流动力学的影响。方法选取2012年6月至2014年7月在中山市小榄人民医院神经内科就诊的脑梗塞患者108例,随机分为治疗组和对照组,每组各54例。对照组患者给予降压、脱水和抗凝等常规治疗,治疗组在对照组的基础上加用注射用丹参多酚酸盐治疗。检测和记录两组患者治疗前后的神经功能缺损(NDS)评分、日常生活能力(ADL)评分、全血高切黏度、全血低切黏度、血细胞比容、血浆黏度、最大峰值流速、舒张末流速、血管搏动指数和血管阻力指数等指标的变化。结果治疗组治疗后的NDS和ADL评分与对照组比较,差异均具有统计学意义(P<0.05);治疗组治疗后全血高切粘度、全血低切黏度、血细胞比容和血浆黏度与对照组比较,差异均具有统计学意义(P<0.05);治疗组治疗后最大峰值流速、舒张末流速、血管搏动指数和血管阻力指数与对照组比较,差异均具有统计学意义(P<0.05)。结论丹参多酚酸盐可以降低脑梗塞患者血液黏滞度,改善脑血流动力学,能有效减少神经功能缺损,提高患者的日常生活能力。

Objective To study the effect of salvianolate on cerebral hemodynamics in patients with cerebral infarction. Methods A total of 108 patients with cerebral infarction from the hospital between June 2012 and July 2014 were selected and randomly divided into treatment group and control group, with 54 patients in each group. Patients in control group were given decompression, dehydration, anticoagulation and other conventional treatments, while patients in treatment group received salvianolate as well as conventional treatments. The neural function defect score（NDS）, activity of daily living（ADL） score, whole blood viscosity, whole blood low shear viscosity, plasma viscosity, hematocrit, peak flow rate, end-diastolic flow velocity, pulsatility index and vascular resistance index before and after treatment in both groups were detected and recorded. Results After treatment, there were statistically significant differences in the NDS and ADL score between the two groups（P〈0.05）,as well as in the whole blood viscosity, whole blood low shear viscosity, hematocrit and plasma viscosity（P〈0.05）,and also in the peak flow rate, end-iastolic flow velocity, pulsatility index and vascular resistance index（P〈0.05）.Conclusion Salvianolate can help reduce blood viscosity and neurological deficit in patients with cerebral infarction, and improve cerebral blood flow dynamics as well as the daily living ability of patients.