靶向超声造影剂在干细胞移植中的研究进展

Research development of targeted ultrasound contrast agent in stem cell transplantation

近年来,干细胞移植技术在心肌梗死的治疗中应用越来越广泛。实验研究发现,靶向超声微泡技术能够有效增强心肌梗死区域局部血管的通透性、提高该区域内相关细胞因子的表达效率、增加梗死区新生血管的形成,从而促进干细胞靶向归巢、改善心功能,提高干细胞移植的成功率。因此,本文通过整理总结相关资料,对将超声联合微泡技术应用于干细胞移植治疗急性心肌梗死过程中的研究进展做一综述。

In recent years, stem cell transplantation technology is more and more widely applied in the treatment of myocardial infarction. Experimental studies have found that, targeted ultrasound microbubble technology can effectively enhance local vascular permeability, improve efficiency of relevant cytokines expression and increase formation of new blood vessels in myocardial infarction areas, and thereby promote stem cell targeting homing, improve cardiac function and increase success rate of stem cell transplantation. Therefore, this article makes a review on the research progress of application of ultrasound combined with microbubble technology in the process of stem cells transplantation in treatment of acute myocardial infarction.