摘要
目的:分析免疫吸附疗法(IA)在急性炎症性脱髓鞘性多发性神经病(AIDP)中的疗效,并与传统的血浆置换疗法(PE)进行对比。方法:分析2011年1月-2014年1月在我院接受治疗的AIDP患者的临床资料,依据患者治疗方法不同分为观察组(IA法治疗)、对照组(PE法治疗)。结果:治疗后2周,观察组患者Hughes评分显著低于对照组(2.31±0.94 vs.2.85±1.02;t=2.085,P=0.042)。治疗后观察组患者C-反应蛋白水平显著低于对照组[(7.21±2.89)mg/L vs.(11.51±3.35)mg/L;t=5.194,P〈0.001)];治疗后观察组患者肿瘤坏死因子-a(TNF-α)水平显著低于对照组[(21.25±7.15)mg/Lvs.(28.40±8.65)mg/L;t=3.400,P=0.001)]。Pearson相关性分析显示,Hughes评分与C-反应蛋白呈现显著性正相关(r=0.463,P〈0.001);Hughes评分与TNF-α呈现显著性正相关(r=0.491,P〈0.001)。结论:免疫吸附疗法治疗AIDP疗效可靠,其清除血浆促炎因子的疗效优于血浆置换。
Objective:To analyze the curative effect of immune adsorption(IA)in the treatment of acute inflammatory demyelinating polyneuropathy(AIDP)compared with that of plasma exchange(PE).Methods:Clinical data of patients with AIDP received treatment at our hospital from 2011 to 2014were analyzed.Patients were divided into two groups by different treatment,Group A:IA;Group B:PE.Results:Two weeks after treatment,patients in Group A had a low level of Hughes scores than that of Group B,the difference was statistically significant(2.31±0.94 vs 2.85±1.02;t=2.085,P=0.042).Group A had lower levels of CRP(7.21±2.89 vs 11.51±3.35;t=5.194,P〈0.001)and TNF-α(21.25±7.15 vs 28.40±8.65;t=3.400,P=0.001)when compared with Group B.Correlation analysis showed that the Hughes scores had significant positive correlation with CRP(r=0.463,P〈0.001)and TNF-α(r=0.491,P〈0.001).Conclusion:In the treatment of AIDP,IA can achieve a better curative effect than that of PE.
出处
《海南医学院学报》
CAS
2015年第4期562-564,共3页
Journal of Hainan Medical University
基金
上海市卫生厅自筹经费科研课题(Z2011129)~~