骨碎补柚皮苷对炎症及骨作用的相关研究进展

Research progress on Drynaria fortunei naringin on inflammation and bone activity

柚皮苷广泛存在于各类植物中,是中药骨碎补的重要组成成分,目前柚皮苷还处于实验研究阶段,已有的实验结论证实了柚皮苷可通过降低炎症因子的表达,实现抑制包括骨关节炎症在内的各种炎症反应的作用,并认为其作用的分子机制是抑制NF-κB通路。此外,柚皮苷通过提高BMP-2蛋白和抑制RANKL的表达实现促进成骨细胞增殖分化和抑制破骨细胞活性的作用。动物实验中柚皮苷对骨质疏松症的治疗有效,其相关机制研究正在深入。

Flavonoid naringin is widely distributed in various types of plants and is an important component of herbal Drynaria. In previous studies,Drynaria has been demonstrated to have inhibitory effects on inflammatory responses and bone destruction and exert anabolic effects on bone,has been widely used in the clinical treatment. Naringin,was in the stage of experimental yet. The experimental results have confirmed that naringin suppressed inflammation including arthritis by lowering the expression of inflammatory cytokines,and the mechanism can be explained as reducing the expression of NF-κB. Naringin has been shown to increase osteoblast proliferation by increasing the expression of BMP-2,inhibit osteoclast activity by reducing the expression of RANKL. In animal experimental,naringin was useful for osteoporosis,and the mechanisms are in depth studies. Research in the field of traditional Chinese medicine and orthopedics,naringin as a explicit material structure in the components of Drynaria,has been concerned about the experimental studies,it is not only prosperity the development of traditional Chinese medicine research,but also ready for clinical studies anti inflammatory and bone effects of naringin in the future.